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研究業績

研究業績

2022.06.01
最新の研究業績は、以下のリサーチマップをご覧ください。
研究業績（リサーチマップ）　小林　茂樹（Kobayashi Shigeki）
論文業績
  1. Fujii S, Kobayashi S, Chang Y, Nawata J, Yoshitomi R, Tanaka S, Kohno M, Nakamura Y, Ishiguchi H, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Yamamoto T, Yano M. RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure. J Mol Cell Cardiol. 2023 Mar 22:S0022-2828(23)00052-4. doi: 10.1016/j.yjmcc.2023.03.007.
  2. Nawata J, Yamamoto T, Tanaka S, Yano Y, Uchida T, Fujii S, Nakamura Y, Suetomi T, Uchinoumi H, Oda T, Kobayashi S, Yano M. Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats. Biochem Biophys Rep. 2023 Mar 1;34:101449. doi: 10.1016/j.bbrep.2023.101449.
  3. Fujioka R, Yamamoto T, Maruta A, Nakamura Y, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M. Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells. Biochem Biophys Res Commun. 2023 Feb 17;652:61-67. doi: 10.1016/j.bbrc.2023.02.038.
  4. Yano Y, Kobayashi S, Uchida T, Chang Y, Nawata J, Fujii S, Nakamura Y, Suetomi T, Uchinoumi H, Oda T, Yamamoto T, Yano M. Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice. Biochem Biophys Res Commun. 2023 Jan 29;642:175-184. doi: 10.1016/j.bbrc.2022.12.063.
  5. Uchida T, Oda T, Yamamoto T, Inamitsu M, Sakai C, Uchinoumi H, Suetomi T, Nakamura Y, Okamoto Y, Tateda S, Fujii S, Tanaka S, Nawata J, Okamura T, Kobayashi S, Yano M. Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells. Biochem Biophys Res Commun. 2022 Nov 5;628:155-162. doi: 10.1016/j.bbrc.2022.08.069.
  6. Ishiguchi H, Uchida M, Okamura T, Kobayashi S, Yano M. Acute heart failure following the initiation of cabozantinib, a multikinase inhibitor: A case report. J Cardiol Cases. 2022 Jul 5;26(3):217-220. doi: 10.1016/j.jccase.2022.04.012.
  7. Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M. Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritisBiochem Biophys Res Commun. 2022 Oct 8;624:141-145. doi: 10.1016/j.bbrc.2022.07.111.
  8. Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, Omuro T, Okamura T, Kobayashi S, Yano M. Long-term events following catheter-ablation for atrial fibrillation in heart failure with preserved ejection fraction ESC Heart Fail. 2022 Oct;9(5):3505-3518. doi: 10.1002/ehf2.14079.
  9. Kobayashi S, Yamamoto T, Yoshiga Y, Okamura T, Kawano R, Yano M. Stabilizing Tetrameric Structure of Ryanodine Receptor Cures Lethal Arrhythmia in Heart Failure.Circ Arrhythm Electrophysiol 2022 Oct;15(10):e011220. doi: 10.1161/CIRCEP.122.011220.
  10. Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, Omuro T, Okamura T, Kobayashi S, Yano M. The Differential Prognostic Impact of Long-Duration Atrial High-Rate Episodes Detected by Cardiac Implantable Electronic Devices between Patients with and without a History of Atrial Fibrillation. J Clin Med. 2022 Mar 21;11(6):1732. doi: 10.3390/jcm11061732.
  11. Sakai C, Mikawa M, Yamamoto T, Uchida T, Nakamura Y, Akase H, Suetomi T, Tominaga N, Inamitsu M, Oda T, Okamura T, Kobayashi S, Yano M. Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice. Biochem Biophys Res Commun. 2022 Oct 1;623:51-58. doi: 10.1016/j.bbrc.2022.07.038.
  12. Ishiguchi H, Uchida M, Sadahiro H, Kimura S, Okamura T,Kobayashi S,Yano M. Acute Cardiac Tamponade Due to Microscopic Venous Invasion of Lung Adenocarcinoma. Circ J. 2022 Mar 19. doi: 10.1253/circj.CJ-22-0059.
  13. Mikawa M, Sakai C, Yamamoto T, Nakamura Y, Tanaka S, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M. Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes. Biochem Biophys Rep. 2022 Mar 16;30:101248. doi: 10.1016/j.bbrep.2022.101248.
  14. Tanaka S, Yamamoto T, Mikawa M, Nawata J, Fujii S, Nakamura Y, Kato T, Fukuda M, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Kobayashi 　S, Yano M. Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension. Heart Rhythm. 2022;S1547-5271(22)00119-9. doi: 10.1161/JAHA.121.023640.
  15. Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, Omuro T, Shimokawa M, Okamura T, Kobayashi S, Yano M. Impact of Atrial Tachyarrhythmia Recurrence on the Development of Long-Term Adverse Clinical Events Following Catheter Ablation in Patients With Atrial Fibrillation With Systolic Impairment: A Single-Center Observational Study. J Am Heart Assoc. 2022;e023640. doi: 10.1161/JAHA.121.023640.
  16. Obayashi M, Kobayashi S, Nanno T, Hamada Y, Yano M. Relation between Oscillometric Measurement of Central Hemodynamics and Left Ventricular Hypertrophy in Hypertensive Patients. Pulse (Basel). 2021;9(3-4):116-124. doi: 10.1159/000520006.
  17. Yoshitomi R, Kobayashi S, Yano Y, Nakashima Y, Fujii S, Nanno T, Ishiguchi H, Fukuda M, Yoshiga Y, Okamura T, Suga K, Kawano R,Yano M. Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis. Heart. 2022;heartjnl-2021-320244. doi: 10.1253/circj.CJ-21-0693.
  18. Nawata T, Kinoshita N, Okuda S, Kubo M, Wada Y, Kobayashi S, Tanaka N, Yano M. Echocardiographic features of acute-phase microscopic polyangiitis in Japanese patients: A single-centre retrospective study. Mod Rheumatol.2021;roab028. doi: 10.1093/mr/roab028.
  19. Ishiguchi H, Okamura T, Nakashima T, Kobayashi S,Yano M. Right Ventricular Outflow Obstruction as an Unusual Presentation of Myocardial Rupture. Circ J. 2022;86(2):332. doi: 10.1253/circj.CJ-21-0693.
  20. Ishiguchi H, Okamura T, Kobayashi S, Yano M. Alternating Bundle Branch Block With Paroxysmal Atrioventricular Block 22 Months After Valve-in-Valve Transcatheter Aortic Valve Replacement. Circ J. 2021 Dec 24;86(1):170. doi: 10.1253/circj.CJ-21-0600.
  21. Omuro T, Yoshiga Y, Ueyama T, Shimizu A, Ono M, Fukuda M, Kato T, Ishiguchi H, Fujii S, Hisaoka M, Kobayashi S,Yano M. An impact of superior vena cava isolation in non-paroxysmal atrial fibrillation patients with low voltage areas. J Arrhythm.2021 May 18;37(4):965-974. doi: 10.1002/joa3.12552.
  22. Ishiguchi H, Shimizu A, Ishikura M, Yoshida M, Imoto K, Sonoyama K, Kawabata T, Sugamori T, Ogawa M, Uchida T, Nakamura T, Morimoto T, Yasuda Y, Tanabe K, Yoshiga Y, Okamura T,Kobayashi S,Yano M, Oda T. Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device – A 10-Year, Single-Center Historical Cohort Study. Circ J. 2021;85(8):1329-1337. doi: 10.1253/circj.CJ-20-1269.
  23. Nakamura Y, Yamamoto T, Xu X, Kobayashi S, Tanaka S, Tamitani M, Saito T, Saido TC, Yano M. Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease. Sci Rep. 2021 Mar 31;11(1):7289. doi: 10.1038/s41598-021-86822-x.
  24. Yasuda Y, Ishiguchi H, Ishikura M, Yoshida M, Imoto K, Sonoyama K, Kawabata T, Okamura T, Endo A, Kobayashi S, Tanabe K,Yano M, Oda T. Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population. Circ J. 2021 Jan 25;85(2):175-184. doi: 10.1253/circj.CJ-20-0955. Epub 2021 Jan 13.
  25. Ishiguchi H, Yasuda Y, Ishikura M, Yoshida M, Imoto K, Sonoyama K, Kawabata T, Okamura T, Endo A, Kobayashi S, Tanabe K, Yano M, Oda T. Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population. Circ J. 2021 Jan 25;85(2):175-184. doi: 10.1253/circj.CJ-20-0955. Epub 2021 Jan 13.
  26. Kohno M, Kobayashi S, Yamamoto T, Yoshitomi R, Kajii T, Fujii S, Nakamura Y, Kato T, Uchinoumi H, Oda T, Okuda S, Watanabe K, Mizukami Y, Yano M. Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling. Commun Biol. 2020 Nov 26;3(1):714. doi: 10.1038/s42003-020-01443-w.
  27. Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M. Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress. Biochem Biophys Rep. 2020 ;23:100787. doi: 10.1016/j.bbrep.2020.100787. eCollection 2020 Sep.
  28. Kobayashi S, Yoshiga Y, Yano M. Author’s reply: The RyR2 – Targeting therapy against lethal arrhythmia. J Cardiol. 2020;76(3):323-324. doi: 10.1016/j.jjcc.2020.03.011.
  29. Sufu-Shimizu Y, Okuda S, Kato T, Nishimura S, Uchinoumi H, Oda T, Kobayashi S, Yamamoto T, Yano M. Stabilizing Cardiac Ryanodine Receptor Prevents the Development of Cardiac Dysfunction and Lethal Arrhythmia in Ca2+/calmodulin-dependent Protein Kinase IIδc Transgenic Mice. Biochem Biophys Res Commun. 2020 Apr 2;524(2):431-438.
  30. Hamada Y, Yamamoto T, Nakamura Y, Sufu-Shimizu Y, Nanno T, Fukuda M, Ono M, Oda T, Okuda S, Ueyama T, Kobayashi S, Yano M. G790del Mutation in DSC2 Alone Is Insufficient to Develop the Pathogenesis of ARVC in a Mouse Model. Biochem Biophys Rep. 2019 Nov 29;21:100711.
  31. Kobayashi S, Wakeyama T, Ono S, Ikeda Y, Omura M, Oda T, Hisamatsu Y, Seki K, Satoh A, Hiromoto M, Akashi S, Uchida K, Harada M, Furutani Y, Nakamura Y, Kohno M, Kawamura S, Obayashi M, Michishige H, Yano M. A Multicenter, Randomized, Double-Blind, Controlled Study to Evaluate the Efficacy and Safety of Dantrolene on Ventricular Arrhythmia as Well as Mortality and Morbidity in Patients With Chronic Heart Failure (SHO-IN Trial): Rationale and Design. J Cardiol. 2020 Apr;75(4):454-461.
  32. Kajii T, Kobayashi S, Shiba S, Fujii S, Tamitani M, Kohno M, Nakamura Y, Nanno T, Kato T, Okuda S, Uchinoumi H, Oda T, Yamamoto T, Yano M. Dantrolene Prevents Ventricular Tachycardia by Stabilizing the Ryanodine Receptor in Pressure- Overload Induced Failing Hearts. Biochem Biophys Res Commun. 2020 Jan 1;521(1):57-63.
  33. Nanno T, Kobayashi S, Yoshitomi R, Fujii S, Kajii T, Kohno M, Ishiguchi H, Okuda S, Okada M, Suga K,　Yano M. Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis. Circ J. 2019 Nov 25;83(12):2494-2504.
  34. Tsutsui H, Isobe M, Ito H, Ito H, Okumura K, Ono M, Kitakaze M, Kinugawa K, Kihara Y, Goto Y, Komuro I, Saiki Y, Saito Y, Sakata Y, Sato N, Sawa Y, Shiose A, Shimizu W, Shimokawa H, Seino Y, Node K, Higo T, Hirayama A, Makaya M, Masuyama T, Murohara T, Momomura SI, Yano M, Yamazaki K, Yamamoto K, Yoshikawa T, Yoshimura M, Akiyama M, Anzai T, Ishihara S, Inomata T, Imamura T, Iwasaki YK, Ohtani T, Onishi K, Kasai T, Kato M, Kawai M, Kinugasa Y, Kinugawa S, Kuratani T, Kobayashi S, Sakata Y, Tanaka A, Toda K, Noda T, Nochioka K, Hatano M, Hidaka T, Fujino T, Makita S, Yamaguchi O, Ikeda U, Kimura T, Kohsaka S, Kosuge M, Yamagishi M, Yamashina A; Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure – Digest Version. Circ J. 2019 Sep 25;83(10):2084-2184.
  35. Yoshiga Y, Okamoto T, Shimizu A, Ueyama T, Ono M, Mito T, Fukuda M, Ishiguchi H, Omuro T, Kobayashi S, Goto A, Nishikawa J, Sakaida I, Yano M. Correlation Between Asymptomatic Gastroesophageal Excessive Transmural Injury After Pulmonary Vein Isolation and a Bonus Freeze Protocol Using the Second-Generation 28-mm Cryoballoon for Paroxysmal Atrial Fibrillation. J Cardiol. 2019 Dec;74(6):494-500.
  36. Nakamura Y, Yamamoto T, Kobayashi S, Tamitani M, Hamada Y, Fukui G, Xu X, Nishimura S, Kato T, Uchinoumi H, Oda T, Okuda S, Yano M. Ryanodine Receptor-Bound Calmodulin Is Essential to Protect Against Catecholaminergic Polymorphic Ventricular Tachycardia. JCI Insight. 2019 Jun 6;4(11):e126112.
  37. Kobayashi S, Myoren T, Kajii T, Kohno M, Nanno T, Ishiguchi H, Nishimura S, Fukuda M, Hino A, Fujimura T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Yoshiga Y, Kawano R, Yano M. Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients With Acute Heart Failure and Rapid Atrial Fibrillation. Cardiology. 2019;142(4):195-202.
  38. Obayashi M, Kobayashi S, Kohno M, Nakashima T, Yano M. Cuff-Based Oscillometric Measurements of Central Hemodynamics: Factors Influencing Central Augmentation Pressure in Normotensive Japanese Individuals. Pulse (Basel). 2019 Apr;6(3-4):161-168.
  39. Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M. Nuclear Translocation of Calmodulin in Pathological Cardiac Hypertrophy Originates From Ryanodine Receptor Bound Calmodulin. J Mol Cell Cardiol. 2018 Dec;125:87-97.
  40. Nawata T, Kubo M, Nomura T, Oishi K, Shiragami K, Ikegami T, Okada M, Kobayashi S, Yano M. Change in Muscle Volume After Steroid Therapy in Patients With Myositis Assessed Using Cross-Sectional Computed Tomography. BMC Musculoskelet Disord. 2018 Mar 27;19(1):93.
  41. Nawata T, Kubo M, Fujii S, Shiragami K, Ikegami T, Kobayashi S, Hisano S, Yano M. Treatment of Class IV Lupus Nephritis With Mycophenolate Mofetil Monotherapy. Intern Med. 2018 Jul 15;57(14):2067-2070.
  42. Ishiguchi H, Kobayashi S, Okuda S, Okamura T, Okada M, Takemura G, Takahashi M, Mikamo A, Hamano K, Yano M. Localized Doxorubicin-Induced Cardiomyopathy Complicated With Shower Emboli Originating From Apical Intramural Thrombi. Circ J. 2018 Aug 24;82(9):2375-2376.
  43. Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Fumimoto T, Ishiguchi H, Omuro T, Kobayashi S, Yano M. Strict Sequential Catheter Ablation Strategy Targeting the Pulmonary Veins and Superior Vena Cava for Persistent Atrial Fibrillation. J Cardiol. 2018 Aug;72(2):128-134.
  44. Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M. Mutation-linked, Excessively Tight Interaction Between the Calmodulin Binding Domain and the C-terminal Domain of the Cardiac Ryanodine Receptor as a Novel Cause of Catecholaminergic Polymorphic Ventricular Tachycardia. Heart Rhythm. 2018 Jun;15(6):905-914.
  45. Okuda S, Sufu-Shimizu Y, Kato T, Fukuda M, Nishimura S, Oda T, Kobayashi S, Yamamoto T, Morimoto S, Yano M. CaMKII-mediated Phosphorylation of RyR2 Plays a Crucial Role in Aberrant Ca2+ Release as an Arrhythmogenic Substrate in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy. Biochem Biophys Res Commun. 2018 Feb 19;496(4):1250-1256.
  46. Ishiguchi H, Kobayashi S, Myoren T, Kohno M, Nanno T, Murakami W, Oda S, Oishi K, Okuda S, Okada M, Suga K, Yano M. Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis. Circ Cardiovasc Imaging. 2017 Dec;10(12): e006764.
  47. Nawata T, Kubo M, Kobayashi S, Nakada N, Maeda M, Cui D, Kimura T, Ikeda E, Yano M. Mucormycete Infiltration in the Cardiac Conduction System. Can J Cardiol. 2018 Jan;34(1):92. e9-92.e10.
  48. Takemura G, Kanamori H, Okada H, Tsujimoto A, Miyazaki N, Miyata S, Ohta H, Kawase Y, Ono M, Mochizuki M, Kobayashi S, Onoue K, Nakano T, Sakaguchi Y, Matsuo H, Yano M, Saito Y. Mitochondrial Deformity Confined to a Single Cardiomyocyte in Human Endomyocardial Biopsy Specimens: Report of 4 Cases. J Cardiol Cases. 2017 Aug 30;16(5):178-182.
  49. Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M. Correction of Impaired Calmodulin Binding to RyR2 as a Novel Therapy for Lethal Arrhythmia in the Pressure-Overloaded Heart Failure. Heart Rhythm. 2017 Jan;14(1):120-127.
  50. Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M. Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage Through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes. PLoS One. 2016 Sep 22;11(9):e0163250.
  51. Myoren T, Kobayashi S, Oda S, Nanno T, Ishiguchi H, Murakami W, Okuda S, Okada M, Takemura G, Suga K, Matsuzaki M, Yano M. An Oxidative Stress Biomarker, Urinary 8-hydroxy-2′-deoxyguanosine, Predicts Cardiovascular-Related Death After Steroid Therapy for Patients With Active Cardiac Sarcoidosis. Int J Cardiol. 2016 Jun 1;212:206-13.
  52. Kobayashi S, Myoren T, Oda S, Inari M, Ishiguchi H, Murakami W, Fukuda M, Tanaka T, Okuda S, Nao T, Doi M, Yamada J, Okamura T, Hoshii Y, Suga K, Matsuzaki M, Yano M. Urinary 8-hydroxy-2′-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients With Cardiac Sarcoidosis. Int J Cardiol. 2015;190:319-28.
  53. Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M. A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum. PLoS One.; 10(1):e0114314, 2015.
  54. Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M. Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes. Biochem Biophys Res Commun 448(1): 1-7, 2014.
  55. Kobayashi S, Mrakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M, Yano M. A Low-Dose β1-Blocker Effectively and Safely Slows the Heart Rate in Patients with Acute Decompensated Heart Failure and Rapid Atrial Fibrillation. Cardiology 127(2) :105-113, 2013.
  56. Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayashi, Kawashiri M, Ino H, Yamagishi M. Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. JACC Heart Failure; 6: 459-466, 2013.
  57. Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Mstsuzaki M. Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts. Cardiovasc Res 96(3):433-443, 2012.
  58. Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M. Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure. Circ J 76(7):1646-1653, 2012.
  59. Susa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Yano M, Matsuzaki M. Urinary 8-Hydroxy-2′-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure. Circ J 76(1):117-126, 2012.
  60. Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca2+ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation 124(6) :682-694, 2011.
  61. Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M. Urinary 8-hydroxy-2´-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure. Eur J Heart Fail 13(2) :29-36, 2011.
  62. Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model. Circ J 74(12):2579-2584, 2010.
  63. Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure. Cardiovasc Res 87(4) :609-617, 2010.
  64. Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun 394(3):660-666, 2010.
  65. Uchinoumi H, Yano M, Suetomi T,Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res 106(8):1413-1424, 2010.
  66. Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor. J Am Coll Cardiol 53(21):1993-2005, 2009.
  67. Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Defective domain-domain interactions within ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res 81(3):1517-1528, 2009.
  68. Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M. Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts. Circulation 117(6):762-772, 2008.
  69. Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Scavenging Free Radicals by Low-Dose Carvedilol Prevents Redox-Dependent Ca2+ Leak Via Stabilization of Ryanodine Receptor in Heart Failure. J Am Coll Cardiol 49(16):1722-1732, 2007.
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  72. Murayama T, Oba T, Kobayashi S, Ikemoto N, Ogawa Y. Postulated role of interdomain interactions within the type 1 ryanodine receptor in the Low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum. Am J Physiol Cell Physiol 288(6):C1222-C1230, 2005.
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  74. Kobayashi S, Yamamoto T, Parness J, Ikemoto N. Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor. Biochem J 380:561-569, 2004.
  75. Okuda S, Yano M, Doi M, Oda T, Tokuhisa T, Kohno M, Kobayashi S, Yamamoto T, Ohkusa T, Matsuzaki M. Valsartan Restores Sarcoplasmic Reticulum Function with No Appreciable Effect on Resting Cardiac Function in Pacing-Induced Heart Failure. Circulation 109(7):911-919, 2004.
  76. Kohno M, Yano M, Kobayashi S, Doi M, Oda T, Tokuhisa T, Okuda S, Ohkusa T, Kohno M, Matsuzaki M. A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. Am J Physiol Heart Circ Physiol 53(3):1035-1042, 2003.
  77. Nao T, Ohkusa T, Hisamatsu Y, Inoue N, Matsumoto T, Yamada J, Shimizu A, Yoshiga Y, Yamagata T, Kobayashi S, Yano M, Hamano K, Matsuzaki M. Comparison of Expression of Connexin in Right Atrial Myocardium in patients with Chronic Atrial Fibrillation versus Those in Sinus Rhythm. Am J Cardiol 91(6):678-683, 2003.
  78. Yano M, Kobayashi S, Kohno M, Doi M, Tokuhisa T, Okuda S, Suetsugu M, Hisaoka T, Obayashi M, Ohkusa T, Kohno M, Matsuzaki M. FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure. Circulation 107(3):477-484, 2003.
  79. Doi M, Yano M, Kobayashi S, Kohno M, Tokuhisa T, Okuda S, Suetsugu M, Hisamatsu Y, Ohkusa T, Kohno M, Matsuzaki M. Propranolol Prevents the Development of Heart Failure by Restoring FKBP12.6-mediated Stabilization of Ryanodine Receptor. Circulation 105(11):1374-1379, 2002.
  80. Yano M, Kohno M, Kobayashi S, Obayashi M, Seki K, Ohkusa T, Miura T, Fujii T, Matsuzaki M. Influence of timing and magnitude of arterial wave reflection on left ventricular relaxation. Am J Physiol Heart Circ Physiol 280(4):H1846-H1852, 2001.
  81. Yamada J, Ohkusa T, Nao T, Ueyama T, Yano M, Kobayashi S, Hamano K, Esato K, Matsuzaki M. Up-Regulation of Inositol 1,4,5 Trisphosphate Receptor Expression in Atrial Tissue in Patients With Chronic Atrial Fibrillation. J Am Coll Cardiol 37(4):1111-1119, 2001.
  82. Hisaoka T, Yano M, Ohkusa T, Suetsugu M, Ono K, Kohno M, Yamada J, Kobayashi S, Kohno M, Matsuzaki M. Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure. Cardiovasc Res 49(2):319-329, 2001.
  83. Tanigawa T, Yano M, Kohno M, Yamamoto T, Hisaoka T, Ono K, Ueyama T, Kobayashi S, Hisamitsu Y, Ohkusa T, Matsuzaki M. Mechanism of preserved positive lusitropy by cAMP-depewndent drugs in heart failure. Am J Physiol Heart Circ Physiol 278:H313-H320, 2000.
  84. Ono K, Yano M, Ohkusa T, Kohno M, Hisaoka T, Tanigawa T, Kobayashi S, Kohno M, Matsuzaki M. Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca2+ release in heart failure. Cardiovasc Res 48(2):323-331, 2000.
  85. Yano M, Ono K, Ohkusa T, Suetsugu M, Kohno M, Hisaoka T, Kobayashi S, Hisamatsu Y, Yamamoto T, Kohno M, Noguchi N, Takasawa S, Okamoto H, Matsuzaki M. Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca2+ Leak Through Ryanodine Receptor in Heart Failure. Circulation102(17):2131-2136, 2000.
  86. Yano M, Kohno M, Ohkusa T, Mochizuki M, Yamada J, Kohno M, Hisaoka T, Ono K, Tanigawa T, Kobayashi S, Matsuzaki M. Effect of Milrinone on Left Ventricular Relaxation and Ca2+ Uptake Function of Cardiac Sarcoplasmic Reticulum. Am J Physiol Heart Circ Physiol 279(4):H1898-H1905, 2000.
  87. Obayashi M, Yano M, Kohno M, Kobayashi S, Yamamoto T, Ohkusa T, Konishi M, Matsuzaki M. Effect of Angiotensin II Receptor Antagonism on Vascular Hypertrophy and Aortic Impedance in Abdominal Aortic-Banded Rat. Am J Hypertens 12(4):381-387, 1999.
  88. Ohkusa T，Hisamatsu Y，Ueyama T，Kobayashi S，Yano M，Maekawa T，Matsuzaki M. Effects of Dantrolene Sodium on Progression of Left Ventricular Hypertrophy Induced by Pressure Overload in Rats. J Cardiovasc Pharmacol 31(4):520-524, 1998.
  89. Obayashi M, Yano M, Kohno M, Kobayashi S, Tanigawa T, Hironaka K, Ryoke T, Matsuzaki M. Dose-dependent effect of ANGⅡ-receptor antagonist on myocyte remodeling in rat cardiac hypertrophy. Am J Physiol Heart Circ Physiol 273(4):H1824-1831, 1997.
  90. Yano M, Kohno M, Konishi M, Obayashi M, Kobayashi S, Seki K, Lee B, Matsuzaki M. Effect of aortic impedance on preload-afterload mismatch in canine hearts in situ. Basic Res Cardiol 92(2) :115-122, 1997.
  91. Ohkusa T, Hisamatsu Y, Yano M, Kobayashi S, Tatsuno H, Saiki Y, Kohno M, Matsuzaki M. Altered Cardiac Mechanism and Sarcoplasmic Reticulum Function in Pressure Overload- Induced Cardiac Hypertrophy in Rats. J Mol Cell Cardiol 29(1) :45-54, 1997.
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