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Publications

  • 2026年
  • 2025年
  • 2024年
  • 2023年
  • 2022年
  • 2021年
  • 2020年以前
  • 受賞歴
  • Patents
  1. Partially Hydrolyzed Guar Gum Suppresses NLRP3 Inflammasome Activation in the Aged Intestinal Epithelium through Gut Microbiota Remodeling and Short-Chain Fatty Acid Production

    2. Akari Shigezumi, Nobuka Tanabe, Takeshi Yamamoto, Ayano Sasakura, Yoshihide Nakamura, Naoomi Tominaga, Masako Inamitsu, Yuki Kobayashi, Kei Sakamoto

    doi: 10.2139/ssrn.6389778.

  2. Contribution between breast cancer stem cells and cancer-associated fibroblasts in breast cancer formation

    3. Risako Okada, Kana Tominaga, Naoomi Tominaga

    CANCER SCIENCE.

  3. Extracellular vesicles-containing Regucalcin suppress tumor development by suppress M2-like macrophage

    4. Naoomi Tominaga, Saki Horie, Risako Okada, Kana Tominaga, Tomiyasu Murata, Masayoshi Yamaguchi

    CANCER SCIENCE.

  4. Differential Circulating miRNA Responses to PM Exposure in Healthy and Diabetes Mellitus Patients: Implications for Lung Cancer Susceptibility
    5. Moe Thi Thi Han, Nichakorn Satitpornbunpot, Naoomi Tominaga, Saranta Freeouf, Khanittha Punturee, Chidchamai Kewchareonwong, Busayamas Chewaskulyong, Ganjana Lertmemongkolchai, Ratchada Cressey

    International Journal of Molecular Sciences. doi: 10.3390/ijms27020613. PMID: 41596268

  5. 4-Phenylbutyric Acid Activates an NF-κB – Egr-1 Axis to Control Myoblast Proliferation and ECM Gene Expression Profiles

    6. Kana Tominaga, Naoomi Tominaga

    doi: https://doi.org/10.64898/2026.01.18.700214.

  6. Regucalcin-containing extracellular vesicles suppress M2 macrophage polarization and attenuate tumor progression in vivo

    7. Risako Okada, Kana Tominaga, Takeshi Yamamoto, Masayoshi Yamaguchi, Naoomi Tominaga

    doi: 10.64898/2026.08.09.743746.

  7. Regucalcin in the Tumor Microenvironment: From Intracellular Tumor Suppression to Putative Extracellular Signaling

    8. Naoomi Tominaga

    Cancers. doi: 10.3390/cancers18162655.

  8. Dantrolene attenuates steatohepatitis and liver fibrosis by suppressing Ca2+ dysregulation.

    9. Juri Sakamoto, Takeshi Yamamoto, Minami Sato, Ayano Sasakura, Yoshihide Nakamura, Naoomi Tominaga, Masako Inamitsu, Naoki Yamamoto, Taro Takami, Motoaki Sano

    Biochemical and biophysical research communications. doi: 10.1016/j.bbrc.2026.154042. PMID: 42217409

  1. Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing Myogenesis

    2. Kana Tominaga, Naoomi Tominaga

    doi: 10.1101/2025.10.02.679938.

  2. Small RNA Profiles of Serum-Derived Extracellular Vesicles in the Comorbid Condition of Frailty and Obstructive Pulmonary Disease: An Observational, Cross-Sectional Study

    3. Keiko Doi, Tsunahiko Hirano, Naoomi Tominaga, Kenji Watanabe, Keiji Oishi, Ayumi Fukatsu-Chikumoto, Tasuku Yamamoto, Yuichi Ohteru, Kazuki Hamada, Yoriyuki Murata, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Yoichi Mizukami, Kazuto Matsunaga

    Biomolecules. doi: 10.3390/biom15121663. PMID: 41463319

  1. Glycosylation state of vWF in circulating extracellular vesicles serves as a novel biomarker for predicting depression

    2. Norihiro Yamada, Kana Tominaga, Naoomi Tominaga, Ayumi Kobayashi, Chihiro Niino, Yuta Miyagi, Hirotaka Yamagata, Shin Nakagawa

    MedRxiv. doi: 10.1101/2024.03.24.24304794.

  2. Glycosylation changes of vWF in circulating extracellular vesicles to predict depression.

    3. Norihiro Yamada, Kana Tominaga, Naoomi Tominaga, Ayumi Kobayashi, Chihiro Niino, Yuta Miyagi, Hirotaka Yamagata, Shin Nakagawa

    Scientific reports. doi: 10.1038/s41598-024-80507-x. PMID: 39580509

  1. Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells

    2. Riko Fujioka, Takeshi Yamamoto, Akihiro Maruta, Yoshihide Nakamura, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano

    Biochemical and Biophysical Research Communications. doi: 10.1016/j.bbrc.2023.02.038. PMID: 36812708

  1. 4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations

    2. Kana Tominaga♰, Naoomi Tominaga♰, Eric O Williams, Laura Rufibach, Verena Schöwel, Simone Spuler, Mohan Viswanathan, Leonard P Guarente
    ♰These authors contributed equally

    iScience. doi: 10.1016/j.isci.2021.103667. PMID: 35028538

  2. Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes

    3. Masafumi Yano Mei Mikawa, Chihiro Sakai, Takeshi Yamamoto, Yoshihide Nakamura, Shinji Tanaka, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Shigeki Kobayashi

    Biochemistry and biophysics reports.. doi: 10.1016/j.bbrep.2022.101248. PMID: 35313646

  3. Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice

    4. Chihiro Sakai, Mei Mikawa, Takeshi Yamamoto, Tomoyuki Uchida, Yoshihide Nakamura, Hideaki Akase, Takeshi Suetomi, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Takayuki Okamura, Shigeki Kobayashi, Masafumi Yano

    Biochemical and biophysical research communications.. doi: 10.1016/j.bbrc.2022.07.038. PMID: 35872542

  1. Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

    2. Nao Nishida-Aoki, Naoomi Tominaga, Nobuyoshi Kosaka, Takahiro Ochiya

    Journal of extracellular vesicles. doi: 10.1080/20013078.2020.1713527. PMID: 32082512

  2. Contribution of Extracellular Vesicles to Cancer Initiation through Cellular Senescence during Aging

    3. N Tominaga

    Cancer Studies.

  3. Indispensable roles of glycosylated extracellular vesicles for cancer cell metastasis

    4. Nobuyoshi Kosaka, Nao Nishida-Aoki, Naoomi Tominaga, Yusuke Yoshioka, Takahiro Ochiya

    CANCER SCIENCE.

  4. Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis

    5. Nao Nishida-Aoki, Naoomi Tominaga, Fumitaka Takeshita, Hikaru Sonoda, Yusuke Yoshioka, Takahiro Ochiya

    Molecular Therapy. doi: 10.1016/j.ymthe.2016.10.009. PMID: 28129113

  5. A novel platform for cancer therapy using extracellular vesicles

    6. Naoomi Tominaga, Yusuke Yoshioka, Takahiro Ochiya

    Advanced Drug Delivery Reviews. doi: 10.1016/j.addr.2015.10.002. PMID: 26482189

  6. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

    7. Nature communications. doi: 10.1038/ncomms7716. PMID: 25828099

  7. Micromanaging of tumor metastasis by extracellular vesicles

    8. Seminars in Cell & Developmental Biology. doi: 10.1016/j.semcdb.2015.02.016. PMID: 25746922

  8. RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy

    9. Naoomi Tominaga, Keitaro Hagiwara, Nobuyoshi Kosaka, Kimi Honma, Hitoshi Nakagama, Takahiro Ochiya

    Molecular cancer. doi: 10.1186/1476-4598-13-134. PMID: 24884960

  9. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

    10. Makiko Ono, Nobuyoshi Kosaka, Naoomi Tominaga, Yusuke Yoshioka, Fumitaka Takeshita, Ryou-u Takahashi, Masayuki Yoshida, Hitoshi Tsuda, Kenji Tamura, Takahiro Ochiya

    Science signaling. doi: 10.1126/scisignal.2005231. PMID: 24985346

  10. Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy

    11. Nobuyoshi Kosaka, Yusuke Yoshioka, Naoomi Tominaga, Keitaro Hagiwara, Takeshi Katsuda, Takahiro Ochiya

    Future Oncology. doi: 10.2217/fon.13.222. PMID: 24754596

  11. Trash or Treasure: extracellular microRNAs and cell-to-cell communication

    12. Nobuyoshi Kosaka, Yoshioka Yusuke, Keitaro Hagiwara, Naoomi Tominaga, Takeshi Katsuda, Takahiro Ochiya

    Frontiers in genetics. doi: 10.3389/fgene.2013.00173. PMID: 24046777

  12. Functional analysis of exosomal microRNA in cell–cell communication research

    13. Nobuyoshi Kosaka, Yusuke Yoshioka, Keitaro Hagiwara, Naoomi Tominaga, Takahiro Ochiya

    Circulating MicroRNAs. doi: 10.1007/978-1-62703-453-1_1. PMID: 23719938

  13. Clinicopathological analysis of GATA3-positive breast cancers with special reference to response to neoadjuvant chemotherapy

    14. N Tominaga, Y Naoi, K Shimazu, T Nakayama, N Maruyama, A Shimomura, SJ Kim, Y Tamaki, S Noguchi

    Annals of oncology. doi: 10.1093/annonc/mds120. PMID: 22767585

  14. 70-Gene classifier for differentiation between paclitaxel-and docetaxel-sensitive breast cancers

    15. Y Naoi, T Tanei, K Kishi, R Tsunashima, N Tominaga, Y Baba, T Nakayama, K Shimazu, SJ Kim, Y Tamaki, S Noguchi

    Cancer letters. doi: 10.1016/j.canlet.2011.09.032. PMID: 22018777

  15. Prediction of pathologic complete response to sequential paclitaxel and 5‐fluorouracil/epirubicin/cyclophosphamide therapy using a 70‐gene classifier for breast cancers

    16. Yasuto Naoi, Kazuki Kishi, Tomonori Tanei, Ryo Tsunashima, Naoomi Tominaga, Yosuke Baba, Seung Jin Kim, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi

    Cancer. doi: 10.1002/cncr.25953. PMID: 21305539

  16. Development of 95-gene classifier as a powerful predictor of recurrences in node-negative and ER-positive breast cancer patients

    17. Yasuto Naoi, Kazuki Kishi, Tomonori Tanei, Ryo Tsunashima, Naoomi Tominaga, Yosuke Baba, Seung Jin Kim, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi

    Breast cancer research and treatment. doi: 10.1007/s10549-010-1145-z. PMID: 20803240

  17. High genomic grade index associated with poor prognosis for lymph node‐negative and estrogen receptor‐positive breast cancers and with good response to chemotherapy

    18. Yasuto Naoi, Kazuki Kishi, Tomonori Tanei, Ryo Tsunashima, Naoomi Tominaga, Yosuke Baba, Seung Jin Kim, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi

    Cancer. doi: 10.1002/cncr.25626. PMID: 20878674

  1. 革新的研究の発掘と育成（FOCS）プロジェクト研究奨励賞受賞

    2. 2023年度FOCSプロジェクト研究奨励賞を受賞いたしました。

  2. 令和6年度学長賞受賞　宮城雄太

  3. Best Poster Award, Breast cancer cell derived-extracellular vesicles promote blood-brain barrier disruption.　富永直臣

  4. Scholarship Award, Breast cancer-derived extracellular vesicles promote brain metastasis via break down BBB, International Society for Extracellular Vesicles (ISEV) 2015　富永直臣

  5. 第３回 Yamaguchi Pitch Day in 松下村塾最優秀賞を受賞いたしました。

  6. ジャパン・ヘルスケアビジネスコンテスト – JHeC 2023竹下幸男氏と優秀賞を受賞いたしました。　富永直臣

  1. Method for suppressing brain metastasis

    2. Takahiro Ochiya, Naoomi Tominaga
    US Patent App. 16/745,967

  2. Method for diagnosing and treating cancer brain metastasis and drug delivery system for enabling passage through blood-brain barrier

    3. Takahiro Ochiya, Naoomi Tominaga
    US Patent 10,544,466

  3. Compositions and methods for treating dysferlinopathy

    4. Leonard P. Guarente, Kana TOMINAGA, Naoomi TOMINAGA, Mohan VISWANATHAN, Eric WILLAMS
    WO2023278684A1

©2021 TOMINAGA LABORATORY. All Rights Reserved.

©2021 TOMINAGA LABORATORY. All Rights Reserved.

©2021 TOMINAGA LABORATORY. All Rights Reserved.

©2021 TOMINAGA LABORATORY. All Rights Reserved.