2023

Yamamoto K, Ohta Y, Taguchi A, Akiyama M, Nakabayashi H, Nagao Y, Ryoko H, Wada Y, Yamamoto T, Yano M, Tanizawa Y. Effects of pemafibrate on left ventricular diastolic function in patients with type 2 diabetes mellitus: a pilot study.
Diabetol Int. 2023 in press doi: 10.1007/s13340-023-00645-x

Kobayashi S, Yamamoto T, Yano M. RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure.
J Mol Cell Cardiol. 2023 Jul 6;182:25-27. doi: 10.1016/j.yjmcc.2023.07.002.

Miura M, Okuda S, Murata K, Ohno Y, Katou S, Nakao F, Ueyama T, Yamamoto T, Ikeda Y. The impact of geriatric nutritional risk index on one-year outcomes in hospitalized elderly patients with heart failure.
Front Cardiovasc Med. 2023 May 30;10:1190548. doi: 10.3389/fcvm.2023.1190548.

Fujii S, Kobayashi S, Chang Y, Nawata J, Yoshitomi R, Tanaka S, Kohno M, Nakamura Y, Ishiguchi H, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Yamamoto T, Yano M. RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure.
J Mol Cell Cardiol. 2023 Mar 22:S0022-2828(23)00052-4. doi: 10.1016/j.yjmcc.2023.03.007.

Nawata J, Yamamoto T, Tanaka S, Yano Y, Uchida T, Fujii S, Nakamura Y, Suetomi T, Uchinoumi H, Oda T, Kobayashi S, Yano M Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats,
Biochem Biophys Rep. 2023 Mar 1;34:101449. doi: 10.1016/j.bbrep.2023.101449.

Fujioka R, Yamamoto T, Maruta A, Nakamura Y, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M. Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells.
Biochem Biophys Res Commun. 2023 Feb 17;652:61-67. doi: 10.1016/j.bbrc.2023.02.038.

2022

Yano Y, Kobayashi S, Uchida T, Chang Y, Nawata J, Fujii S, Nakamura Y, Suetomi T, Uchinoumi H, Oda T, Yamamoto T, Yano M. Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice.
Biochem Biophys Res Commun. 2023 Jan 29;642:175-184. doi: 10.1016/j.bbrc.2022.12.063.

Kobayashi S, Yamamoto T, Yoshiga Y, Okamura T, Kawano R, Yano M.
Stabilizing Tetrameric Structure of Ryanodine Receptor Cures Lethal Arrhythmia in Heart Failure.
Circ Arrhythm Electrophysiol. 2022 Oct;15(10):e011220. doi: 10.1161/CIRCEP.122.011220.

Uchida T, Oda T, Yamamoto T, Inamitsu M, Sakai C, Uchinoumi H, Suetomi T, Nakamura Y, Okamoto Y, Tateda S, Fujii S, Tanaka S, Nawata J, Okamura T, Kobayashi S, Yano M. Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells.
Biochem Biophys Res Commun. 2022 Nov 5;628:155-162. doi: 10.1016/j.bbrc.2022.08.069.

Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M. Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.
Biochem Biophys Res Commun. 2022 Oct 8;624:141-145. doi: 10.1016/j.bbrc.2022.07.111.

Sakai C, Mikawa M, Yamamoto T, Uchida T, Nakamura Y, Akase H, Suetomi T, Tominaga N, Inamitsu M, Oda T, Okamura T, Kobayashi D, Yano M
Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice Biochem Biophys Res Commun. 2022 in press

Tanabe N, Kodama E, Matsui M, Wakuda K, Fujiwara K, Tsutsumi M, Yamamoto T
Importance of Nutrition Support Team in Pressure Ulcer Control: Examination at One Long-term Care Hospital in Yamaguchi Prefecture　The Bulltetin of the Yamaguchi Medical School 2022, 69(3-4

Mikawa M, Sakai C, Yamamoto T, Nakamura Y, Tanaka S, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M. Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes.
Biochem Biophys Rep. 2022 Mar 16;30:101248.

Tanaka S, Yamamoto T, Mikawa M, Nawata J, Fujii S, Nakamura Y, Kato T, Fukuda M, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Kobayashi S, Yano M. Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Heart Rhythm. 2022 Feb 5:S1547-5271(22)00119-9.

Maruta A, Sakai C, Mikawa M, Akita H, Inamitsu M, Fujioka R, Saiki Y, Yamamoto T Low-cost and High-Precision Stepping Motor Controlled Multi-Point Automatic Time-Lapse Microscope.
the Bulletin of the Yamaguchi Medical School 2021, 68(3-4) 41-47

Nakamura Y, Yamamoto T, Xu X, Kobayashi S, Tanaka S, Tamitani S, Saito T, Saido T, Yano M
Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease
Scientific Rep 2021, 11(1) 7289-7289

Utsunomiya T, Mimura-Kimura Y, Yamamoto T, Aoe K, Oishi K, Kamei H, Matsunaga K, Yano M, Mimura Y.
Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study.
Blood Purif. 2020 Sep 7:1-8. doi: 10.1159/000510290. Online ahead of print.2.116

Kohno M, Kobayashi S, Yamamoto T, Yoshitomi R, Kajii T, Fujii S, Nakamura Y, MD, Kato T, Uchinoumi H, Oda T, Okuda S, Watanabe K, Mizukami Y, Yano M.
Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling
Communications Biology 3, Article number: 714 (2020)

Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M.
Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress. Biochem Biophys Rep. 2020 Jul 21;23:100787. .

Nakayama Y, Isoyama N, Yamamoto T, Nagata Y, Matsumura M, Fujikawa K, Matsuyama H, Shiraishi K.
Receptor activator of the NFκB ligand system protects renal function during experimental renal ischemia-reperfusion in mice.Transpl Immunol. 2020 Feb;58:101263. doi: 10.1016/j.trim.2020.101263

Sufu-Shimizu Y, Okuda S, Kato T, Nishimura S, Uchinoumi H, Oda T, Kobayashi S, Yamamoto T, Yano M.
Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice. Biochem Biophys Res Commun. 2020 Apr 2;524(2):431-438..

Tadaki S, Sakata Y, Miura Y, Nochioka K, Miura M, Miyata S, Asakura M, Shimada K, Yamamoto T, Fukumoto Y, Kadokami T, Yasuda S, Miura T, Ando SI, Yano M, Kitakaze M, Daida H, Shimokawa H.
Factors limiting habitual exercise in patients with chronic heart failure: a multicenter prospective cohort study.　Heart Vessels. 2020 May;35(5):655-664.

Nakayama Y, Isoyama N, Yamamoto T, Nagata Y, Matsumura M, Fujikawa K, Matsuyama H, Shiraishi K.
Receptor activator of the NFκB ligand system protects renal function during experimental renal ischemia-reperfusion in mice.
Transpl Immunol. 2020 Feb;58:101263.

Hamada Y, Yamamoto T, Nakamura Y, Sufu-Shimizu Y, Nanno T, Fukuda M, Ono M, Oda T, Okuda S, Ueyama T, Kobayashi S, Yano M.
G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model. Biochem Biophys Rep. 2019 Nov 29;21:100711.

Kajii T, Kobayashi S, Shiba S, Fujii S, Tamitani M, Kohno M, Nakamura Y, Nanno T, Kato T, Okuda S, Uchinoumi H, Oda T, Yamamoto T, Yano M.
Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts. Biochem Biophys Res Commun. 2020 Jan 1;521(1):57-63.

Nakamura Y, Yamamoto T, Kobayashi S, Tamitani M, Hamada Y, Fukui G, Xu X, Nishimura S, Kato T, Uchinoumi H, Oda T, Okuda S, Yano M
Ryanodine receptor bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia
JCI insght 2019 Jun 6;4(11). pii: 126112.

Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M.
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
J Mol Cell Cardiol. 2018 Dec;125:87-97.

Murayama R, Kimura-Asami M, Togo-Ohno M, Yamasaki-Kato Y, Naruse TK, Yamamoto T, Hayashi T, Ai T, Spoonamore KG, Kovacs RJ, Vatta M, Iizuka M, Saito M, Wani S, Hiraoka Y, Kimura A, Kuroyanagi H.
Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization.
Sci Rep. 2018 Jun 12;8(1):8970. doi: 10.1038/s41598-018-26624-w

Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.
Heart Rhythm. 2018 Feb 7. pii: S1547-5271(18)30101-2. doi: 10.1016/j.hrthm.2018.02.006.

Okuda S, Sufu-Shimizu Y, Kato T, Fukuda M, Nishimura S, Oda T, Kobayashi S, Yamamoto T, Morimoto S, Yano M.
CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.
Biochem Biophys Res Commun. 2018 Feb 19;496(4):1250-1256. doi: 10.1016/j.bbrc.2018.01.181

2018以前

Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.
Heart Rhythm. 2017 Jan;14(1):120-127. doi: 10.1016/j.hrthm.2016.10.019.

Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S
Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension.
. Circ J. 2017;81:1360-1367. doi: 10.1253/circj.CJ-16-1348.

Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M.
Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.
PLoS One. 2016 Sep 22;11(9):e0163250. doi: 10.1371/journal.pone.0163250.

Tadaki S, Sakata Y, Miura Y, Miyata S, Asakura M, Shimada K, Yamamoto T, Fukumoto Y, Kadokami T, Yasuda S, Miura T, Ando S, Yano M, Kitakaze M, Daida H, Shimokawa H.
Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure　- A Multicenter Prospective Cohort Study.
Circ J. 2016;80(3):677-88. doi: 10.1253/circj.CJ-15-0942.

Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM.
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.
J Mol Cell Cardiol. 2015 Aug;85:240-8. doi: 10.1016/j.yjmcc.2015.06.009.

Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M.
A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.
PLoS One. 2015 Jan 23;10(1):e0114314. doi: 10.1371/journal.pone.0114314.

Uchida K, Wada Y, Ariyoshi T, Okuda S, Murakami W, Myoren T, Harada N, Yamamoto T, Ueyama T, Tanaka N, Yano M.
Kinetics of left ventricular rotation during exercise and its relation to exercise tolerance in atrial fibrillation: assessment by two-dimensional speckle tracking echocardiography.
J Echocardiogr. 2014 Sep;12(3):89-97. doi: 10.1007/s12574-014-0205-5.

Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.
Biochem Biophys Res Commun. 2014 May 23;448(1):1-7. doi: 10.1016/j.bbrc.2014.03.152.

Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts. Cardiovasc Res. 2012; 96(3):433-43. doi: 10.1093/cvr/cvs271.

Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M. Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca² release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation. 2011;124(6):682-94. doi: 10.1161/CIRCULATIONAHA.111.023259.

Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model.
Circ J. 2010 Nov;74(12):2579-84.

Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M. Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling. Cardiovasc Res. 2011;89(1):79-88. doi: 10.1093/cvr/cvq252.

Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure. Cardiovasc Res. 2010 May 19.

Ando M, Yamamoto T, Hino A, Sato T, Nakamura Y, Matsuzaki M. Norepinephrine spillover during exercise as a novel parameter to evaluate the severity of heart failure. J Nucl Cardiol. 2010 May 26.

Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6.

Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res. 2010 Apr 30;106(8):1413-24.

Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009 May 26;53(21):1993-2005.

Yano M, Yamamoto T, Kobayashi S, Matsuzaki M. Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts. J Cardiol. 2009 Feb;53(1):1-7. Epub 2008 Dec 10.

Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res. 2009 Feb 15;81(3):536-45.
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Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M. Defective Ca2+ cycling as a key pathogenic mechanism of heart failure. Circ J. 2008;72 Suppl A:A22-30. Epub 2008 Sep 4. Review.

Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M. Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts. Circulation. 2008 Feb 12;117(6):762-72.

Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol. 2007 Apr 24;49(16):1722-32. Epub 2007 Apr 5.

Tokuhisa T, Yano M, Obayashi M, Noma T, Mochizuki M, Oda T, Okuda S, Doi M, Liu J, Ikeda Y, Yamamoto T, Ohkusa T, Matsuzaki M. AT1 receptor antagonist restores cardiac ryanodine receptor function, rendering isoproterenol-induced failing heart less susceptible to Ca2+ -leak induced by oxidative stress. Circ J. 2006 Jun;70(6):777-86.

Hadano Y, Murata K, Yamamoto T, Kunichika H, Matsumoto T, Akagawa E, Sato T, Tanaka T, Nose Y, Tanaka N, Matsuzaki M. Usefulness of mitral annular velocity in predicting exercise tolerance in patients with impaired left ventricular systolic function. Am J Cardiol. 2006 Apr 1;97(7):1025-8.

Yano M, Yamamoto T, Ikeda Y, Matsuzaki M. Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.
Nat Clin Pract Cardiovasc Med. 2006 Jan;3(1):43-52. Review.

Yano M, Okuda S, Oda T, Tokuhisa T, Tateishi H, Mochizuki M, Noma T, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. Circulation. 2005 Dec 6;112(23):3633-43.

Oda T, Yano M, Yamamoto T, Tokuhisa T, Okuda S, Doi M, Ohkusa T, Ikeda Y, Kobayashi S, Ikemoto N, Matsuzaki M. Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure. Circulation. 2005 Jun 28;111(25):3400-10.

Yano M, Yamamoto T, Ikemoto N, Matsuzaki M. Abnormal ryanodine receptor function in heart failure. Pharmacol Ther. 2005 Sep;107(3):377-91.

Paul-Pletzer K, Yamamoto T, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Ma J, Parness J. Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. Biochem J. 2005;387:905-9.

Kobayashi S, Yamamoto T, Parness J, Ikemoto N. Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor. Biochem J. 2004;380:561-9.

Paul-Pletzer K, Yamamoto T, Bhat MB, Ma J, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Parness J. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem. 2002;277:34918-23.

Yamamoto T, Ikemoto N. Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor. Biochem Biophys Res Commun. 2002;291:1102-8.

Ikemoto N, Yamamoto T. Regulation of calcium release by interdomain interaction within ryanodine receptors. Front Biosci. 2002;7:d671-83

Yamamoto T, Ikemoto N. Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor. Biochemistry. 2002;41:1492-501.

Shtifman A, Ward CW, Yamamoto T, Wang J, Olbinski B, Valdivia HH, Ikemoto N, Schneider MF. Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle. J Gen Physiol. 2002;119:15-32.

Yamamoto T, Rodriguez J, Ikemoto N. Ca2+-dependent dual functions of peptide C. The peptide corresponding to the Glu724-Pro760 region (the so-called determinant of excitation-contraction coupling) of the dihydropyridine receptor alpha 1 subunit II-III loop. J Biol Chem. 2002;277:993-1001

Yamamoto T, Ikemoto N. T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A. J Biol Chem. 2002 ;277:984-92.

Lamb GD, Posterino GS, Yamamoto T, Ikemoto N. Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers. Am J Physiol Cell Physiol. 2001;281:C207-14.

Ikemoto N, Yamamoto T. Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation. Trends Cardiovasc Med. 2000;10:310-6.

Ikemoto N, Yamamoto T. The luminal Ca2+ transient controls Ca2+ release/re-uptake of sarcoplasmic reticulum. Biochem Biophys Res Commun. 2000;279:858-63.

Yamamoto T, El-Hayek R, Ikemoto N. Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation. J Biol Chem. 2000;275:11618-25.

Yano M, Ono K, Ohkusa T, Suetsugu M, Kohno M, Hisaoka T, Kobayashi S, Hisamatsu Y, Yamamoto T, Kohno M, Noguchi N, Takasawa S, Okamoto H, Matsuzaki M. Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. Circulation. 2000;102:2131-6.

Tanigawa T, Yano M, Kohno M, Yamamoto T, Hisaoka T, Ono K, Ueyama T, Kobayashi S, Hisamatsu Y, Ohkusa T, Matsuzaki M. Mechanism of preserved positive lusitropy by cAMP-dependent drugs in heart failure. Am J Physiol Heart Circ Physiol. 2000;278:H313-20.

El-Hayek R, Saiki Y, Yamamoto T, Ikemoto N. A postulated role of the near amino-terminal domain of the ryanodine receptor in the regulation of the sarcoplasmic reticulum Ca(2+) channel. J Biol Chem. 1999;274:33341-7.

Yamamoto T, Yano M, Kohno M, Hisaoka T, Ono K, Tanigawa T, Saiki Y, Hisamatsu Y, Ohkusa T, Matsuzaki M. Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure. Cardiovasc Res. 1999;44:146-55.

Obayashi M, Yano M, Kohno M, Kobayashi S, Yamamoto T, Ohkusa T, Konishi M, Matsuzaki M. Effect of angiotensin II receptor antagonism on vascular hypertrophy and aortic impedance in abdominal aortic-banded rat. Am J Hypertens. 1999;12:381-7.

Hayano T, Shimizu A, Ikeda Y, Yamamoto T, Yamagata T, Ueyama T, Furutani Y, Matsuzaki M. Paradoxical effects of pirenzepine on parasympathetic activity in chronic heart failure and control. Int J Cardiol. 1999;68:47-56.

Yano M, Kohno M, Yamamoto T, Hisaoka T, Tanigawa T, Ono K, Lee B, Konishi M, Matsuzaki M. Effects of balanced vasodilator, flosequinan, on aortic impedance in failing heart. J Cardiovasc Pharmacol. 1998;32:466-70.

Yano M, Yamamoto T, Kohno M, Hisaoka T, Ono K, Tanigawa T, Ueyama T, Ohkusa T, Matsuzaki M. Polylysine-induced rapid Ca2+ release from cardiac sarcoplasmic reticulum. J Cardiovasc Pharmacol. 1998;32:96-100.

Shiigi T, Furutani Y, Nakamura Y, Nakamura H, Harada M, Yamamoto T, Shimizu A, Matsuzaki M. Relative usefulness of measures of heart rate variability and neuroendocrine activity as indicators of autonomic nervous abnormality in patients with left ventricular dysfunction. Jpn Circ J. 1998;62:336-40.

Ueyama T, Ohkusa T, Hisamatsu Y, Nakamura Y, Yamamoto T, Yano M, Matsuzaki M. Alterations in cardiac SR Ca(2+)-release channels during development of heart failure in cardiomyopathic hamsters. Am J Physiol. 1998;274:H1-7.

Furutani Y, Shiigi T, Nakamura Y, Nakamura H, Harada M, Yamamoto T, Wakeyama T, Nakatsuka M, Ogawa H, Matsuzaki M. Quantification of area at risk in acute myocardial infarction by tomographic imaging. J Nucl Med. 1997;38:1875-82.