Yamaguchi University Graduate School of Medicine

Department of Systems Bioinformatics

In preparation for the advent of Society 5.0, a human-centric society realized by a system that seamlessly integrates the cyber and physical spaces- there is a nationwide accelerated push for enhancement in data science education. In the field of medical science too, there's a demand for education in data science, including AI, and its technologies are already starting to be introduced. Our department aims to introduce the rapidly advancing data science technology into medical education and scientific research, striving to push one step ahead.


What's New

April 11, 2025
We have updated our website style.
April 04, 2025
We had a brief meeting with the FY2025 new students in the members of the Introduction to Medicine course.
January 07, 2025
Prof Asai received the Yamaguchi University Best Teaching Award.
Learn more
October 01, 2024
Administrative assistant Ms. Konomi Amahata has taken up her new post.
September 30, 2024
Administrative assistant Ms. Midori Takenaka has resigned.
October 01, 2023
Prof. Asai has been appointed the Head of the Division of Systems Medicine and Informatics at the Research Institute for Cell Design Medical Science.
Learn more
April 01, 2018
Prof. Asai has been appointed the Director of the AI Systems Medicine Research and Training Center.
April 01, 2017
Lecturer Takahide Hayano has taken up his new post.
April 01, 2017
The name of the department has been changed from the Dept. Environmental Health Medicine to the Dept. Systems Bioinformatics.
October 01, 2016
Prof. Yoshiyuki Asai has taken up his new post.

Message from Professor

Professor's Image

I assumed my position at Yamaguchi University Graduate School of Medical Sciences in October 2016. In April 2017, with the goal of steadily advancing systems medicine and medical AI by utilizing artificial intelligence (AI), systems biology, and bioinformatics, the long-standing Department of Environmental Health Sciences (formerly Department of Hygiene) was renamed to the Department of Systems Bioinformatics.
In recent years, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) has been promoting data science education. At Yamaguchi University School of Medicine, our department has been at the forefront of this initiative, striving to assist medical students in becoming future data science doctors. To achieve this, naturally, solid research applying AI, Systems Biology, and Bioinformatics to medical science is fundamental. We are also keen on collaborative research with both clinical and foundational departments, aiming to enhance the research capabilities of our medical school and, more broadly, contribute to the advancement of medical research in Japan.
Medical AI has the potential for early and accurate diagnosis and prediction of therapeutic effects. Systems Biology offers a powerful analytical method that mathematically captures the dynamics of physiological functions, leading to a deeper understanding and paving the way for the development of new treatments. From a biological perspective, Bioinformatics, which analyzes the blueprint of physiological functions, i.e., genomic information, in detail, serves as its foundation. Skillfully integrating these 3DS technologies -AI, systems biology, and bioinformatics- in the field of medical science, our staff and I are dedicated to medical education and research.

Professor Yoshiyuki Asai

Members


Unit Members

Professor
  Yoshiyuki Asai
Senior Lecturer
  Takahide Hayano
Unit Assistant
  Konomi Amahata

Research Cooperation Members

Yamaguchi Univ. AI Systems Medicine Research and Training Center (AISMEC)
  Spec. App. Prof. Masahiko Nakatsui
Yamaguchi Univ. AI Systems Medicine Research and Training Center (AISMEC)
  Vis. Assoc. Prof. Koji Hazama
Yamaguchi Univ. AI Systems Medicine Research and Training Center (AISMEC)
  Asst. Prof. Takeshi Abe
Yamaguchi Univ. AI Systems Medicine Research and Training Center (AISMEC)
  Spec. App. Asst. Prof. Shinichi Hisamatsukousinn

Students

PhD Course (2022-)
  A.H.M Fahad

Collaborators

Lausanne University, Neuroheuristic Research Group
  Prof. Alessandro E.P. Villa

Previous Members

Assistant Professor
  Natsu Yamaguchi
Unit Assistant
  Midori Takenaka

Alumni

PhD Course (2020-2023)
  Kazuki Hamada
FY2024, Self Development Course
  Kose Ikeda
FY2024, Self Development Course
  Kosuke Ikeda
FY2024, Self Development Course
  Junyoung Kang
FY2024, Self Development Course
  Yudai Tokunaga
FY2024, Self Development Course
  Soichiro Tokura
FY2024, Self Development Course
  Taigo Nawata
FY2024, Self Development Course
  Tomomi Hirayama
FY2023, Self Development Course
  Fumiya Takase
FY2023, Self Development Course
  Daisuke Kodo
FY2023, Self Development Course
  Norinao Uchida
FY2023, Self Development Course
  Asahi Kitano
FY2022, Self Development Course
  Yusuke Saikawa
FY2022, Self Development Course
  Tsugumi Sakai
FY2022, Self Development Course
  Kimihiro Doi
FY2021, Self Development Course
  Akihiro Kagita
FY2021, Self Development Course
  Takahiro Emoto
FY2021, Self Development Course
  Hiroki Yoshida
FY2020, Self Development Course
  Yuta Kawahara
FY2020, Self Development Course
  Ryoga Nishimura
FY2020, Self Development Course
  Kazuki Onoue
FY2020, Self Development Course
  Lucas Hiroshi Imamura
FY2019, Self Development Course
  Taro Yasuhi
FY2019, Self Development Course
  Masashi Dotare
FY2019, Self Development Course
  Tomohisa Nakano
FY2019, Self Development Course
  Yumi Nakaguchi
FY2018, Self Development Course
  Keito Ishiyama
FY2017, Self Development Course
  Shuji Kawakami

Research Achievements

  • Role of long noncoding RNA leucinerich repeat containing 75 Aantisense RNA1 in the invasion and progression of renal cell carcinoma. Takanori Tokunaga, Hiroshi Hirata, Yukihiro Hitaka, Nakanori Fujii, Keita Kobayashi, Takahide Hayano, Yoshiyuki Asai, Koji Shiraishi. Oncology reports, 53(1), 2025. doi:10.3892/or.2024.8844
  • Detection of quadratic phase coupling by cross-bicoherence and spectral Granger causality in bifrequencies interactions. Takeshi Abe, Yoshiyuki Asai, Alessandra Lintas, Alessandro E. P. Villa. Scientific Reports , 14, Article number: 8521, 2024.
  • Reply to “Questioning Bayesian Inference‐Based Models for Estimating Culprit Drugs for Adverse Drug Reactions.” Kazuki Hamada, Takeshi Abe, Kyoji Kouda, Masahiko Nakatsui, Takashi Kitahara, Kazuto Matsunaga, Yoshiyuki Asai. Clinical Pharmacology & Therapeutics , 2023.
  • Estimating Culprit Drugs for Adverse Drug Reactions based on Bayesian Inference. Kazuki Hamada, Takeshi Abe, Kyoji Kouda, Masahiko Nakatsui, Takashi Kitahara, Kazuto Matsunaga, Yoshiyuki Asai. Clinical pharmacology and therapeutics, 2023.
  • Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki. Nature communications 13(1) 6948-6948, 2022.
  • 仮説駆動型の医学からデータ駆動型の医学へ. 浅井義之, 早野崇英, 安部武志, 中津井雅彦. 月刊Precision Medicine, 5(12) 2022.
  • Dissonance Between Human Nurses And Technology: Understanding Nurses’ Experience Using Technology Beds With Monitoring Functions Within Clinical Nursing Practice. Kazuko Kotoku, Eri Eguchi, Hideyuki Kobayashi, Shota Nakashima, Yoshiyuki Asai, Jun Nishikawa. The Open Nursing Journal, 16(1), 2022.
  • 臨床看護師と人工知能技術の共同は可能か −転倒転落防止センサ活用方法への提案−. 神徳和子, 江口恵里, 中島翔太, 浅井義之, 小林秀幸, 西川潤. Medical Science Digest, 48(8) 35-38, 2022.
  • 多施設共有医薬品Q&Aシステムの構築. 幸田 恭治, 谷澤 香名子, 有馬 秀樹, 越智 文也, 吉井 稔紀, 西中 芳幸, 李 俐, 浅井 義之, 北原 隆志. 日本医薬品情報学会総会・学術大会講演要旨集 第24回, 126-126, 2022.
  • 機械学習モデルは喘息における呼吸機能低下を予測する. 濱田 和希, 松永 和人, 浅井 義之, 村田 順之, 大石 景士, 山路 義和, 浅見 麻紀, 枝國 信貴, 平野 綱彦, 安部 武志, 中津井 雅彦. 日本呼吸器学会誌 11(増刊) 197-197, 2022.
  • 人工知能(AI)とシステムバイオロジーによる病院における医療支援システム構築に向けて. 浅井義之, 安部武志, 早野崇英, 中津井雅彦. 日本糖尿病情報学会誌, 20, 2022.
  • Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina. Yuka Kobayashi, Shizuka Watanabe, Agnes Lee Chen Ong, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, Noriaki Sasai, Kazuhiro Kimura. Disease Models & Mechanisms, 14(11) 2021.
  • AIによる副作用の原因薬剤推定および喘息診療における予測システムの開発と、その実用化に向けた取り組み. 濱田 和希, 安部 武志, 早野 崇英, 中津井 雅彦, 幸田 恭治, 北原 隆志, 松永 和人, 浅井 義之. 山口医学, 70(3) 138-138, 2021.
  • Autologous multilayered fibroblast sheets can reinforce bronchial stump in a rat model. Sota Yoshimine, Koji Ueno, Junichi Murakami, Toshiro Saito, Ryo Suzuki, Yoshiyuki Asai, Eiji Ikeda, Toshiki Tanaka, Kimikazu Hamano. Seminars in Thoracic and Cardiovascular Surgery, 34(1) 349-358, 2021.
  • Causal Interactions Among Cortical Regions During Sleep Based on fNIRS Recordings. Takeshi Abe, Yoshiyuki Asai, Masashi Dotare, Takahide Hayano, Stephen H. Perrig, Manon Jaquerod, Alessandra Lintas, Alessandro E. P. Villa. Advances in Cognitive Neurodynamics (VII), 273-274, 2021.
  • An Integrated Genomic Approach Identifies HOXC8 as an Upstream Regulator in Ovarian Endometrioma. Yumiko Mihara, Ryo Maekawa, Shun Sato, Natsuko Shimizu, Yumiko Doi-Tanaka, Haruka Takagi, Yuichiro Shirafuta, Masahiro Shinagawa, Isao Tamura, Toshiaki Taketani, Hiroshi Tamura, Takeshi Abe, Yoshiyuki Asai, Norihiro Sugino. The Journal of clinical endocrinology and metabolism, 105(12) 2020.
  • Attention Networks in ADHD Adults after Working Memory Training with a Dual n-Back Task. Masashi Dotare, Michel Bader, Sarah K. Mesrobian, Yoshiyuki Asai, Alessandro E. P. Villa, Alessandra Lintas. Brain Sciences, 10(10), 2020.
  • Flint: a simulator for biological and physiological models in ordinary and stochastic differential equations. Takeshi Abe, Yoshiyuki Asai. Journal of Open Source Software, 5(53) 2331-2331, 2020.
  • Integrative and theoretical research on the architecture of a biological system and its disorder. Uchida S, Asai Y, Kariya Y, Tsumoto K, Hibino H, Honma M, Abe T, Nin F, Kurata Y, Furutani K, Suzuki H, Kitano H, Inoue R, Kurachi Y. The journal of physiological sciences : JPS, 69(3) 433-451, 2019.
  • Granger Causality to Reveal Functional Connectivity in the Mouse Basal Ganglia-Thalamocortical Circuit. Alessandra Lintas, Takeshi Abe, Alessandro E, P. Villa, Yoshiyuki Asai. Artificial Neural Networks and Machine Learning - ICANN 2018 - 27th International Conference on Artificial Neural Networks, Rhodes, Greece, October 4-7, 2018, Proceedings, Part II 11140 LNCS 393-402 2018.
  • 人工知能とシステムバイオロジーによる新時代の医学医療. Asai Yoshiyuki, Abe Takeshi, Hayano Takahide. Nihon Hoshasen Gijutsu Gakkai zasshi 74(11) 1343-1351, 2018.