- Basic Veterinary Science
- Veterinary Anatomy and Histology
- Veterinary Pharmacology
- Veterinary Physiology and Biochemistry
- Biomedical Science-Developmental Genetics
- Veterinary Microbiology
- Pathogenetic and Preventive Veterinary Science
- Veterinary Epidemiology
- Veterinary Pathology
- Veterinary Hygiene
- Veterinary Public Health
- Veterinary Parasitology
- Clinical Veterinary Science
- Veterinary Surgery
- Veterinary Radiology
- Veterinary Internal Medicine
- Veterinary Clinical Pathology
- Veterinary Theriogenology
- Preventive Physiology and Management
- Large Animal Clinic
- Veterinary Diagnosis and Development Center
- One Welfare Education and Research Center
- Animal Medical Center
- National BioResource Project Paramecium
- Yamaguchi University Joint Graduate School of Veterinary Medicine
Veterinary Pharmacology
Faculty
SATO Koichi, PhD, DVM
Professor, Veterinary Pharmacology
OHAMA Takashi, PhD, DVM
Associate Professor, Laboratory of Veterinary Pharmacology
Our Lab
<Investigate the microenvironment of the intestinal mucosa>
Because the digestive organs are connected to the outside the body directly, is exposed to various alien substances and bacteria, a food antigen. Therefore there are many serious diseases that intestinal epithelial cells are related to, for example, inflammatory bowel disease, cancer, and diarrhea. The intestinal epithelium is converted into an always new cell by repeating controlled death and regeneration, and plays a role as a primary breakwater for those alien. We think that this intestinal epithelium is regulated not only by itself, but also by the micro environment around the cell (it is called "Niche"). We focus on to the intestinal epithelium and myofibroblasts to elucidate the control mechanism, and study about these cells and niche. In addition, we study about the phosphorylation of protein playing as a switch of the signal transduction in the cell from the viewpoint of dephosphorylation control (phosphatase control) mechanism.
Research Interests
- Micro-environment consist of mucosal epithelial cells and myofibroblast.
- Physiological and pathophysiological roles of protease-activated receptors.
- Control mechanism of autophagy by Type2A phosphatase.
- Role of Type2A phosphatase in cell canceration mechanism.