2025.07.18
High-Concentration Hydrogen Delivery During Dialysis Using an Innovative Direct Dissolution Technique: In Vivo Kinetics in a Canine Model.
A research group at Yamaguchi University Graduate School of Medicine has developed a new dialysis technology utilizing hydrogen to reduce oxidative stress, a cause of complications in dialysis patients.
While hemodialysis is essential for sustaining life, the use of artificial organs causes chronic inflammation and oxidative stress within the body, leading to fatigue and complications.
To address this challenge, the research group collaborated with a company to develop a unique technology using a “gas separation hollow fiber membrane.” This enables the generation of hydrogen-enriched dialysis water more efficiently and safely than conventional methods.
This new technology is expected to contribute to improving the quality of life (QOL) for dialysis patients.
- Division of Advanced Genome Editing Therapy
- （Medicine and Clinical Science）
- Naohito Isoyama（Urolog）
- Division of Translational Research for One Medicine
- Kenji Tani（Clinical Veterinary Science）
- Paper Title：High-Concentration Hydrogen Delivery During Dialysis Using an Innovative Direct Dissolution Technique: In Vivo Kinetics in a Canine Model.
「A Method for Supplying High-Concentration Hydrogen During Dialysis Using Innovative Direct Dissolution Technology—In Vivo Dynamics in a Canine Model」 - Auther：Shibuya, Masaki; Fujinaka, Masafumi; Yonezawa, Mako; Nishimura, Natsumi; Uchinoumi, Hitoshi; Tani, Kenji; Hitaka, Yukihiro; Nakamura, Kimihiko; Isoyama, Naohito; Fujii, Zenzo; Sano, Motoaki
- Publication：ASAIO Journal
- Publication Date: July 15, 2025
- DOI：https://doi.org/10.1097/MAT.0000000000002508
＜Regarding Hydrogen Water Dialysis＞
Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
Masaki Shibuya
Phone: 0836-22-2248
Email: mshibuya@yamaguchi-u.ac.jp
＜Regarding Hydrogen Medicine in General＞
Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
Motoaki Sano
Phone: 0836-22-2244
Email: msano@yamaguchi-u.ac.jp
<Regarding Beagle Dog Experiments>
Department of Joint Faculty of Veterinary Medicine, Yamaguchi University Joint Veterinary Medical School
Kenji Tani
Phone: 083-933-5908
Email: ktani@yamaguchi-u.ac.jp
＜Regarding Public Relations＞
Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Research Institute Division, Academic Research Department)
Tel: 0836-85-3065
Email: sh088@yamaguchi-u.ac.jp