News

Riboflavin transporter: Evidence of a role as entry receptor for chimpanzee endogenous retrovirus

*Report* External Lecturer Seminar (Division of Advanced Genome Editing Therapy) was held.

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice

*Information* Seminar co-hosted with the Department of Systems Bioinformatics on June 17

*Report* The 1st Research Institute for Cell Design Medical Science Colloquium was held

*Information* Why can newts “super-regenerate”? Molecular Mechanisms of Organ Regeneration will be held on June 10.

*Information* We will hold an in-house seminar “Development of Gastroenterological, Breast and Endocrine Surgery” on Tuesday, June 17

Small nuclear ribonucleoprotein autoantibody associated with blood-nerve barrier breakdown in Guillain-Barré syndrome

Two distinct mechanisms of PP2A regulation by methylesterase PME-1 are both essential for mouse development

*Announcement* Phase I/IIa Clinical Trial of Human (Allogeneic) Subcutaneous Adipose Tissue-Derived Mesenchymal Stem Cell Sheet (PAL-222) Transplantation in Neovascular Age-Related Macular Degeneration Refractory to Existing Treatments (Trial Title: PRESERVE Study)

Pilot study of autologous multilayered fibroblast sheet transplantation for reinforcing bronchial stump healing after pulmonary lobectomy in a canine model

Innovative Treatment of Ankylosing Dystrophy with a Novel RNA-Targeted Protein

*Announcement* Crowdfunding Goal Reached

*Report* Open Seminar of the Division of Advanced Genome Editing Therapy was held.

Sodium ferrous citrate in 5-Aminolevulinic acid supplements suppresses the effector function of feline lymphocytes by reducing the mitochondrial membrane potential

*Announcement* Presentation at the Lunch Meeting of the Research Institute and Center Conference

*Notice* Currently exhibiting at the Osaka-Kansai Expo pre-event!

*Notice* UBE Corporation and UBE Corporation Commence Joint Research on Novel Combination Cancer Immunotherapy

Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease

Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs

*Notice* We are challenging crowdfunding!

Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy

*Report* “The Frontiers of Regenerative and Cellular Medicine: Changing the Future of Medicine” was held as an open-house event.

*Report* Seminar on Medical Information Systems Research was held.

Establishment of a novel amyotrophic lateral sclerosis patient (TARDBP N345K/+)-derived brain microvascular endothelial cell model reveals defective Wnt/β-catenin signaling: investigating diffusion barrier dysfunction and immune cell interaction.

*Report* FOCS Project Selected

*Information* Seminar of the Division of Medical Informatics and Systems Research will be held on December 13.

*Information* Open-house event “The Frontiers of Regenerative and Cellular Medicine: Changing the Future of Medicine” will be held on December 17.

*Information* Symposium on Multi-level Systems Medicine “New Challenges to Intractable Diseases by Artificial Intelligence and Systems Medicine” will be held on November 30.

Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan.

*Announcement* We exhibited at BioJapan2024.

Calcineurin-mediated dephosphorylation stabilizes E2F1 protein by suppressing binding of the FBXW7 ubiquitin ligase subunit

*Report* International exchange with Yamaguchi Center for Arts and Media (YCAM) in different fields.

Establishment of Noninvasive Prediction Models for the Diagnosis of Uterine Leiomyoma Subtypes

*Announcement* Comprehensive Collaborative Agreement with Pharmaceutical Research Institute, Pharmaceutical Division of UBE Co.

*Report* Director Tamada held a seminar for the staff of Pharmaceutical Research Laboratory, Pharmaceutical Division, UBE Co.

Therapeutic efficacy of IL-7/CCL19-expressing CAR-T cells in intractable solid tumor models of glioblastoma and pancreatic cancer

Endogenous retrovirus ERV-DC8 highly integrated in domestic cat populations is a replication-competent provirus

*Report* International Seminar on Novel Armored CAR-T therapy for patients with hematological malignancies was held.

*Announcement* Attended the joint press conference (Establishment of the joint research course “Tissue Regeneration and Therapy”)

*Information* Joint Symposium “New Technologies Starting from Next Generation Sequencing” will be held by Yamaguchi University Research Promotion Organization, Center for Integrated Science Experimentation and Institute for Cell Design and Medical Science, Yamaguchi University on November 1st.

*Information* A seminar on “Novel Armored CAR-T therapy for patients with hematological malignancies” will be held on Thursday, September 5, 2012 at Institute for Cell Design and Medical Science, Division of Advanced Cell Therapy Research.

*Announcement* We have opened Instagram

Nuclear actin assembly is an integral part of decidualization in human endometrial stromal cells

Size and Surface Properties of Functionalized Organosilica Particles Impact Cell–Particle Interactions Including Mitochondrial Activity

*Announcement* Participated in AMED Cancer Symposium “Shiru x Shiru x Michiru: Past and Future of Cancer Research

*Information* “Toward Data-driven Stratification of Mental Disorders Using Various Modalities”, Seminar of Systems Medicine and Information Research Division, Institute for Cell Design and Medical Science, will be held on Wednesday, June 13.

*Announcement* Received the 2024 National Commendation for Invention, Future Invention Encouragement Award.

miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation

*Report* Seminar on “Systems Medicine Information Analysis as a Hub for Accelerating Research Collaboration” held by the Systems Medicine Information Research Division, Research Institute for Cell Design and Medical Science

*Announcement* Comprehensive Collaborative Agreement with the Japan Small Animal Medical Center (JSAMC)

Combination Assay of Methylated HOXA1 with Tumor Markers Shows High Sensitivity for Detection of Early-Stage Hepatocellular Carcinoma

Multi-electrode Electroretinography with Transparent Microelectrodes Printed on a Soft and Wet Contact Lens

E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis

*Report* International Symposium (YU-COH Biomedical Research Partnership “ Exchange Expansions 2024”) was held.

PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells

The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction

The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.

*Information* International Symposium (YU-COH Biomedical Research Partnership “ Exchange Expansions 2024”) will be held on Wednesday, April 24.

Detection of quadratic phase coupling by cross-bicoherence and spectral Granger causality in bifrequencies interactions

*Information* Seminar on “Systems Medicine Information Analysis as a Hub for Accelerating Research Collaboration” will be held on May 15 (Wed.) at Institute for Cell Design and Medical Science, Division of Systems Medicine Information Research.

Cellular Distribution and Intracellular Localization of Different Sizes of Fluorescent Thiol-Organosilica Particles in Mouse Lungs

*Announcement* Signs have been installed at the Yoshida Campus.

*Announcement* Membership to the Council for Research Institutes and Centers of Japan National University.

FeLIX is a restriction factor for mammalian retrovirus infection

*Report* “Challenges of Basic Course Professors at Regional Universities” was held.

*Article published* Article in the Ube Nippo

*Article published* Article in Nikkei Biotech

*Announcement* Comprehensive Collaborative Agreement with Hiroshima University Genome Editing Innovation Center

*Report* Symposium was held to commemorate the establishment of the Research Institute for Cell Design Medicine.

*Information* Symposium to commemorate the establishment will be held on Wednesday, February 28.

Establishment of African pygmy mouse induced pluripotent stem cells using defined doxycycline inducible transcription factors

*Information* “Challenges of Basic Course Professors at Local Universities” will be held on Thursday, March 7.

Multiple Recombination Events between Endogenous Retroviral Elements and Feline Leukemia Virus

Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors

Erythromycin for myotonic dystrophy type 1: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

*Article published* An article was published in the Nikkei Newspaper.

*Announcement* Press Conference and Ribbon-Cutting Ceremony for the Establishment of the Company was held.

*Announcement* We have launched our website.