2026.05.18
Incidence and risk factors of acute blood pressure drops during circular-array pulsed-field ablation for pulmonary vein isolation
A research group led by Clinical Assistant Professor Shintaro Hashimoto, Assistant Professor Hironori Ishiguchi, Lecturer Yasuhiro Yoshiga, and Professor Motoaki Sano at the Graduate School of Medicine, Yamaguchi University, has clarified the frequency, risk factors, and preventive measures for sudden blood pressure drops that occur during Pulsed Field Ablation (PFA), the latest catheter-based treatment for atrial fibrillation.
While PFA—which utilizes non-thermal electrical energy—is rapidly gaining popularity as a revolutionary treatment with minimal damage to surrounding tissues, transient drops in blood pressure immediately after energy delivery have remained a clinical challenge. This study analyzed in detail how the “sequencing of targeted pulmonary veins” affects blood pressure when using a circular PFA system.
These findings were published in Heart Rhythm, the official journal of the Heart Rhythm Society.
- Division of Advanced Genome Editing Therapy
- Shigeki Kobayashi (Endowed Chairs: Department of Therapeutic Science for Heart Failure in the Elderly)
- Motoaki Sano (Medicine and Clinical Science)
- Title：Incidence and Risk Factors of Acute Blood Pressure Drops During Circular-Array Pulsed-Field Ablation for Pulmonary Vein Isolation
- Authors：Shintaro Hashimoto, Hironori Ishiguchi, Yasuhiro Yoshiga, Masakazu Fukuda, Goki Nakashima, Takuya Omuro, Shigeki Kobayashi, Motoaki Sano
- Journal：Heart Rhythm（the official Journal of the Heart Rhythm Society ）
- DOI：10.1016/j.hrthm.2026.02.050
- ＜Research Inquiries＞
- Hironori Ishiguchi
- Assistant Professor, Medicine and Clinical Science at Graduate School of Medicine, Yamaguchi University
- TEL：0836-22-2248
- E-mail：hishigu@（followed by yamaguchi-u.ac.jp）
- ＜Regarding public relations＞
- Yamaguchi University Research Institute for Cell Design Medical Science (Life Science Support Section, Academic Research Division)
- TEL: 0836-85-3065
- E-mail: sh088@ ( followed by yamaguchi-u.ac.jp)