2026.05.25
Extracellular vesicle microRNAs from human bone marrow MSCs suppress fibrogenesis of hepatic stellate cells by downregulation of RhoA signaling
The research achievement by Dr. Toshihiko Matsumoto and Dr. Taro Takami (Gastroenterology and Hepatology) of the Division of Advanced Cell Therapy has been accepted for publication in the journal Stem Cells.
They reported the mechanism by which bone marrow-derived mesenchymal stromal cells suppress the fibrogenesis of hepatic stellate cells via microRNAs within extracellular vesicles.
These findings could potentially lead to the development of next-generation therapeutic strategies for liver cirrhosis using synthetic microRNAs.
- Division of Advanced Cell Therapy
- Toshihiko Matsumoto (Gastroenterology and Hepatology)
- Taro Takami (Gastroenterology and Hepatology)
- Title：Extracellular vesicle microRNAs from human bone marrow MSCs suppress fibrogenesis of hepatic stellate cells by downregulation of RhoA signaling
- Authors：Daiki Kawamoto, Toshihiko Matsumoto, Tsuyoshi Fujioka, Shuhei Shinoda, Koichi Fujisawa, Tsuyoshi Ishikawa, Naoki Yamamoto, Taro Takami
- Journal：Stem Cells
- Publication Date：February , 2026
- URL：https://doi.org/10.1093/stmcls/sxag006
- ＜Regarding the Research＞
- Toshihiko Matumoto （Gastroenterology and Hepatology）
- Graduate School of Medicine,
- Yamaguchi University
- Tel：0836-22-2241
- E-mail：tm0831@（followed by yamaguchi-u.ac.jp）
- ＜Regarding Public Relations＞
- Research Institute for Cell Design Medical Science (RICeD)
- (Research Support Division, Life Science Support Section, Yamaguchi University)
- Tel: 0836-85-3065
- E-mail: sh088@ (followed by yamaguchi-u.ac.jp)