2024.01.26
Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors
A research group from the Yamaguchi University Joint Veterinary Medical School, in collaboration with Nippon Zenyaku Kogyo Co., Ltd., has developed “ca-4F12-E6,” a drug for treating malignant tumors in dogs.
While previous research confirmed its efficacy against oral melanoma, a new clinical trial was conducted on 38 dogs with advanced malignant tumors to clarify its effects on other tumors.
Analysis revealed a “complete response”—complete tumor disappearance—in one dog each with squamous cell carcinoma and undifferentiated sarcoma. Tumor shrinkage was also confirmed in a lung cancer case. These results suggest the drug could become a new treatment option for canine tumors beyond oral melanoma.
These research findings were published in advance on January 11, 2024, in the Journal of Veterinary Science.
- Division of Translational Research for One Medicine
- Takuya Mizuno (Clinical Veterinary Science)
- Masaya Igase (Clinical Veterinary Science)
- Title：“Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors”
- Authors：Masaya Igase, Sakuya Inanaga, Shoma Nishibori, Kazuhito Itamoto, Hiroshi Sunahara, Yuki Nemoto, Kenji Tani, Hiro Horikirizono, Munekazu Nakaichi, Kenji Baba, Satoshi Kambayashi, Masaru Okuda, Yusuke Sakai, Masashi Sakurai, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno.
- Publication：Journal of Veterinary Science
- Publication Date: January 11, 2024 (Online Release)
- DOI：https://doi.org/10.4142/jvs.23144
- ＜Regarding the content of the paper＞
- Clinical Veterinary Science, Yamaguchi University Joint Veterinary Medical School
- Professor Takuya Mizuno
- 1677-1 Yoshida, Yamaguchi City, 753-8515
- E-mail: mizutaku@yamaguchi-u.ac.jp
- Related URL: https://mizutakuvet.com/
- ＜Regarding Public Relations＞
- Yamaguchi University Research Institute for Cell Design Medical Science (Life Science Support Section, Academic Research Division)
- Tel: 0836-85-3065
- E-mail: sh088@yamaguchi-u.ac.jp