日本語 EN 中文

2024.01.29

Multiple Recombination Events between Endogenous Retroviral Elements and Feline Leukemia Virus

Overview


A research team led by Professor Kazuo Nishigaki at Yamaguchi University has elucidated the mechanism by which ancient retroviruses remaining within genes are reactivated when modern retroviruses infect domestic cats, leading to the emergence of new pathogenic viruses.
Similar to “endogenous retroviruses (ERVs)” which comprise about 8% of the human genome, ancient retroviral gene sequences also exist within the genome of domestic cats. These ancient viruses are typically suppressed and non-pathogenic. However, the study revealed that when domestic cats are infected with feline leukemia virus (FeLV), a retroviral infection, recombination with ERVs can generate new viruses capable of causing lymphoma and leukemia. This suggests that ancient viral records can regain pathogenicity triggered by modern viral infections.
These research findings were published in the Journal of Virology.

RICeD Member
  • Division of Translational Research for One Medicine
  • 　　　Kazuo Nishigaki (Pathogenetic and Preventive Veterinary Science)
Paper Information
  • Title：Multiple Recombination Events between Endogenous Retroviral Elements and Feline Leukemia Virus
  • Authors：Minh Ha Ngo, Loai AbuEed, Junna Kawasaki, Naoki Oishi, Didik Pramono, Toru Kimura, Yu Sakurai, Kenji Watanabe, Yoichi Mizukami, Haruyo Ochi, Yukari Anai, Yuka Odawara, Daigo Umehara, Maki Kawamura, Shinya Watanabe, Saiko Miyake*, Kazuo Nishigaki
  • *Corresponding authors
  • Affiliation：
    Department of Veterinary Infectious Diseases, Yamaguchi University Joint Veterinary Medical School: Minh Ha Ngo, Loai AbuEed, Didik Pramono, Haruyo Ochi, Yukari Anai, Yuka Odawara, Daigo Umehara, Shinya Watanabe, Saiko Miyake, Kazuo Nishigaki
  • Department of Veterinary Pathology, Yamaguchi University Joint Veterinary Medical School: Yu Sakurai
  • Graduate School of Veterinary Medicine, Yamaguchi University: Toru Kimura
  • Yamaguchi University, University Research Promotion Organization, Comprehensive Science Experiment Center: Kenji Watanabe, Yoichi Mizukami
  • Yamaguchi University, General Engineering Department: Maki Kawamura
  • Oishi Animal Hospital: Naoki Oishi
  • Waseda University, Institute for Advanced Science and Engineering: Junna Kawasaki
  • Journal: Journal of Virology
  • Publication Date: January 19, 2024
  • DOI：https://doi.org/10.1128/jvi.01400-23
Contact
  • ＜Research Inquiries＞
  • Yamaguchi University
  • Pathogenetic and Preventive Veterinary Science
  • Kazuo Nishigaki
  • E-mail: kaz@（address@ followed by →yamaguchi-u.ac.jp）
  • ＜Public Relations Inquiries＞
  • Yamaguchi University Research Institute for Cell Design Medical Science
  • (Life Science Support Section, Research Institute Division, Academic Research Department)
  • Tel: 0836-85-3065
  • E-mail: sh088@（address@ followed by →yamaguchi-u.ac.jp）

Back