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2024.05.07

E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis

Overview


A research group at Yamaguchi University Graduate School has revealed through collaborative research that the output clock gene E4BP4 in macrophages contributes to improving the pathology of colitis.
Inflammatory bowel disease (IBD) is an inflammation of the digestive tract with unknown causes, and the number of patients has been increasing in recent years. Current treatments do not achieve a cure.
This study focused on clock genes that regulate the body’s internal rhythms. Increasing E4BP4 expression in inflammatory cells reduced the severity of colitis in mice. These findings suggest that optimizing circadian rhythms may improve IBD and contribute to developing new treatments targeting E4BP4.
The research results were published in the scientific journal『 Communications Biology』.

RICeD Member
  • Division of Advanced Cell Therapy　
  • 　　　Akihiko Taguchi（Endocrinology，Metabolism, Hematological Sciences and Therapeutics）
  • 　　　Yasuharu Ohta　（Endocrinology，Metabolism, Hematological Sciences and Therapeutics）
Paper Information
  • Title：E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis
    Macrophage E4BP4 mobilizes anti-inflammatory macrophages and reduces the severity of colitis.
  • Authors：Yasuko Kajimura, Akihiko Taguchi, Yuko Nagao, Kaoru Yamamoto, Konosuke Masuda, Kensuke Shibata, Yoichi Asaoka, Makoto Furutani-Seiki, Yukio Tanizawa, Yasuharu Ohta
    Yasuko Kajimura, Akihiko Taguchi (responsible author), Yuko Nagao, Kaoru Yamamoto, Kanosuke Masuda, Kensuke Shibata, Yoichi Asaoka, Makoto Kiyoki, Yukio Tanizawa, Yasuharu Ota
  • Publication：Communications Biology
  • Release Date: May 7, 2024 (10:00 AM London time)
  • DOI：https://doi.org/10.1038/s42003-024-06099-4
Contact
  • ＜Research Inquiries＞
  • Endocrinology，Metabolism, Hematological Sciences and Therapeutics, Yamaguchi University
  • Lecturer Akihiko Taguchi
  • Phone: 0836-22-2251
  • E-mail: a.tgc@yamaguchi-u.ac.jp
  • ＜Public Relations＞
  • Yamaguchi University Research Institute for Cell Design Medical Science (Life Science Support Section, Academic Research Division)
  • Tel: 0836-85-3065
  • E-mail: sh088@yamaguchi-u.ac.jp

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