2025.01.16
Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy
A research group at Yamaguchi University has discovered that short-term administration of the existing drug dantrolene can prevent the cardiac side effects (cardiotoxicity) caused by the anticancer drug doxorubicin.
Doxorubicin is effective in treating many cancers, but its significant side effect of cardiotoxicity has limited its use. This study demonstrated in mice the mechanism by which doxorubicin causes cardiotoxicity: it binds to the type 2 ryanodine receptor (RyR2) in heart cells, leading to excessive calcium ion leakage.
Furthermore, it was revealed that co-administration of dantrolene stabilizes the structure of RyR2, suppresses calcium ion leakage, and inhibits the decline in cardiac function.
This discovery represents a significant achievement leading to drug repositioning, enabling the clinical application of dantrolene as a preventive drug for cardiotoxicity. This research was published in “JACC: CardioOncology.”
- Division of Advanced Genome Editing Therapy
- Motoaki Sano（Medicine and Clinical Science）
- Yoshihide Nakamura（Medicine and Clinical Science）
- Paper Title：Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy
- Author：Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Takeshi Suetomi,Hitoshi Uchinoumi, Tetsuro Oda, Motoaki Sano, Masafumi Yano
- Journal: JACC: CardioOncology
- Publication Date: December 10, 2024, 19:00 UTC
- DOI：https://doi.org/10.1016/j.jaccao.2024.10.011
＜Research Inquiries＞
Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
Yoshihide Nakamura
Tel: 0836-22-2248
E-mail: yoshi44@yamaguchi-u.ac.jp
Researcher Information: https://researchmap.jp/yoshihide44
＜Public Relations＞
Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Academic Research Division)
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