2025.01.27
Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs
A research group from Yamaguchi University’s Graduate School of Medicine and Joint Faculty of Veterinary Medicine has, for the first time globally, clarified the movement of hydrogen within the body during hydrogen infusion using experiments with pigs.
Hydrogen gas, known for its antioxidant properties, is anticipated as a treatment for various diseases, but its effects within the body depending on the administration method remained unclear.
The study found that when hydrogen was administered intravenously to pigs, the hydrogen was significantly diluted before reaching the heart. Furthermore, almost all of it was exhaled as breath when passing through the lungs, meaning it was not delivered to the arteries carrying blood from the heart to the rest of the body.
This discovery provides important insights for scientifically evaluating the therapeutic effects of hydrogen infusion therapy and is expected to contribute to future research on hydrogen therapy.
- Division of Advanced Genome Editing Therapy
- Motoaki Sano（Medicine and Clinical Science）
- Division of Translational Research for One Medicine
- Kenji Tani（Clinical Veterinary Science）
- Paper Title：Pharmacokinetics of hydrogen during hydrogen-saturated saline infusion in pigs
- Author：Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, Kenji Tani, Eiji Kobayashi and Motoaki Sano
- Publication：Biomedicines
- Posted on: January 19, 2025
- DOI：https://doi.org/10.3390/biomedicines13010234
＜Research Inquiries＞
Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
Masaki Shibuya
Phone: 0836-22-2248
E-mail: mshibuya@yamaguchi-u.ac.jp
＜General Hydrogen Medicine＞
Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
Motoaki Sano
Phone: 0836-22-2244
Email: msano@yamaguchi-u.ac.jp
<Regarding Medical-Veterinary Collaboration>
Department of Clinical Veterinary Science, Yamaguchi University Joint Faculty of Veterinary Medicine
Kenji Tani
Phone: 083-933-5908
E-mail: ktani@yamaguchi-u.ac.jp
＜Public Relations＞
Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Research Institute Division, Academic Research Department)
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