2025.06.06
Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice
A research group at Yamaguchi University Graduate School of Medicine has revealed for the first time worldwide that even a single dose of NMN, a substance noted for its anti-aging effects, improves metabolism.
NMN is a precursor to NAD+, which is crucial for energy metabolism in the body. While the effects of long-term NMN administration had been reported, the impact of a single dose remained unknown.
In the study, a single NMN dose administered to healthy young mice suppressed lipid release from adipose tissue and the liver while improving systemic insulin sensitivity.
This discovery represents a significant finding that could lead to the development of new treatments for metabolic diseases such as diabetes and obesity.
The research findings are scheduled for publication in the journal Endocrine Journal.
- Division of Advanced Genome Editing Therapy
- Akihiko Taguchi（Internal Medicine Ⅲ）
- Yasuharu Ota（Endocrinology, Metabolism, Hematological Sciences and Therapeutics）
- Paper Title：Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice
- Author：Shunsuke Hiroshige†, Yasuko Kajimura†, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta
- Journal：Endocrine Journal（Scheduled for publication in September 2025）
- D O I：https://doi.org/10.1507/endocrj.EJ24-0312
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Department of Pathophysiology and Internal Medicine, Graduate School of Medicine, Yamaguchi University
TEL: 0836-22-2251
Akihiko Taguchi
E-mail: a.tgc@yamaguchi-u.ac.jp
Yasuharu Ota
E-mail: yohta@yamaguchi-u.ac.jp
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Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Research Institute Division, Academic Research Department)
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