2025.07.24
Wound-healing effects of frozen-thawed allogeneic fibroblast sheet transplantation and xenogeneic fibroblast cell sheet transplantation cultured on a new substrate
【Allogeneic Fibroblast Sheets Suitable for Cryopreservation Effective in Treating Refractory Ulcers】
A research group from Yamaguchi University and Central Glass Co., Ltd. has reported the therapeutic efficacy of allogeneic cryopreserved fibroblast sheets using the newly developed substrate “CY-1.” This cell sheet can be mass-produced and cryopreserved, then thawed and transplanted as needed, contributing to cost reduction in regenerative medicine.
The study confirmed that this cell sheet demonstrated excellent therapeutic effects in mouse skin ulcer models and rat esophageal suture models. Using CY-1 also established a seamless method from cell sheet production to transplantation.
These research findings are anticipated as a new treatment option for refractory ulcers. Joint research continues, aiming for early clinical application.
- Division of Advanced Cell Therapy
- Kimikazu Hamano（Surgery and Clinical Science）
- Koji Ueno（Surgery and Clinical Science）
- Taro Takami（Gastroenterology and Hepatology）
- Mouse Skin Ulcer Model
- Paper Title：Wound-healing effects of frozen-thawed allogeneic fibroblast sheet transplantation and xenogeneic fibroblast cell sheet transplantation cultured on a new substrate
- Author：Yutaro Suto, Koji Ueno, Hiroshi Kurazumi, Wataru Kawai, Keita Yoshida, Koji Harada, Tomoko Kondo, Tomoaki Murata, Taro Takami, Kimikazu Hamano
- Publication：Tissue and Cell
- Posted on: March 28, 2025
- DOI：https://doi.org/10.1016/j.tice.2025.102888
- Rat Esophageal Suture Model
- Paper Title：Development of Frozen-thawed Allogeneic Fibroblast Sheets for Esophageal Anastomotic Leakage
- Author：Ryunosuke Sakamoto, Koji Ueno, Yoshihiro Takemoto, Hiroshi Kurazumi, Yuya Tanaka, Keita Yoshida, Wataru Kawai, Atsunori Oga, Taro Takami, Kimikazu Hamano
- Publication：Surgery
- Posted on: July 12, 2025
- DOI：https://doi.org/10.1016/j.surg.2025.109538
＜Research Inquiries＞
Department of Surgery and Clinical Science, Graduate School of Medicine, Yamaguchi University
Koji Ueno
Tel: 0836-22-2261
E-mail: kjueno@yamaguchi-u.ac.jp
Researcher Profile: https://researchmap.jp/7000022357
＜Public Relations＞
Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Academic Research Division)
Tel: 0836-85-3065
E-mail: sh088@yamaguchi-u.ac.jp