2025.08.06
Comparison of post ablation left atrial volume index versus left atrial reverse remodeling for prognostic events in persistent atrial fibrillation
A research group led by Assistant Professor Ishiguchi, Lecturer Yoshiga, and Professor Sano at Yamaguchi University has discovered a new method for predicting long-term prognosis in persistent atrial fibrillation. Atrial fibrillation is an arrhythmia that increases with aging and frequently leads to heart failure.
Catheter ablation, a curative treatment, has the effect of reducing left atrial volume (reverse remodeling). Previous studies suggested that both post-ablation left atrial volume and reverse remodeling are associated with prognosis, but it was unclear which was superior for predicting long-term cardiovascular events.
This study directly compared these two indicators and clarified their detailed relationship. This is expected to enable more accurate prognosis prediction.
- Division of Advanced Genome Editing Therapy
- Motoaki Sano（Medicine and Clinical Science）
- Paper Title：Comparison of Post Ablation Left Atrial Volume Index versus Left Atrial ReverseRemodeling for Prognostic Events in Persistent Atrial Fibrillation
- Author：Hironori Ishiguchi, Yasuhiro Yoshiga, Masakazu Fukuda, Shohei Fuji, Masahiro Hisaoka, Shintaro Hashimoto, Takuya Omuro, Noriko Fukue, Shigeki Kobayashi, Motoaki Sano
- Publication：Scientific Reports
- Publication Date: July 28, 2025
- DOI：https://doi.org/10.1038/s41598-025-13311-w
- ＜Research Inquiries＞
- Department of Medicine and Clinical Science Graduate School of Medicine, Yamaguchi University
- Hironori Ishiguchi
- Phone: 0836-22-2248
- E-MAIL: hishigu@yamaguchi-u.ac.jp
- ＜Public Relations＞
- Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Academic Research Division)
- Tel: 0836-85-3065
- E-mail: sh088@yamaguchi-u.ac.jp