2025.09.29
Lactic acid regulates antitumor immunity in canine invasive urothelial carcinoma
A research group led by Assistant Professor Masaya Igasese and Professor Takuya Mizuno at the Graduate School of Veterinary Medicine, Yamaguchi University, in collaboration with the University of Tokyo and others, has elucidated the molecular mechanism by which “lactic acid” secreted by tumor cells suppresses antitumor immunity in canine invasive urothelial carcinoma (iUC).
While canine iUC is known for high regulatory T cell (Treg) infiltration, this study revealed that expression of the lactate efflux transporter MCT4 positively correlates with HER2 gene expression and Treg infiltration numbers.
These findings are expected to lead to the development of new treatments for canine iUC.
- Division of Translational Research for One Medicine
- Masaya Igase（Clinical Veterinary Science）
- Masashi Sakurai （Pathogenetic and Preventive Veterinary Science）
- Takuya Mizuno（Clinical Veterinary Science）
- Paper Title: Lactic acid regulates antitumor immunity in canine invasive urothelial carcinoma
- Journal: PLOS ONE
- Publication Date: September 18, 2025 (online publication)
- Authors: Taiki Kato, Nao Okauchi, Tomoki Motegi, Masashi Sakurai, Shingo Maeda, Daiki Kato, Takayuki Nakagawa, Kazuyuki Uchida, Takuya Mizuno, Masaya Igase
- DOI: https://doi.org/10.1371/journal.pone.0332825
＜Research-related inquiries＞
Joint Faculty of Veterinary Medicine, Yamaguchi University
Masaya Igase
Email: m.igase@（Address after @→yamaguchi-u.ac.jp）
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Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Research Institute Division, Academic Research Department)
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