2025.11.12
CXCL8 mediates macrophage migration in canine oral malignant melanoma
A research group led by Associate Professor Masaya Iga and Professor Takuya Mizuno at the Yamaguchi University Joint Veterinary Medical School has elucidated the molecular basis of macrophage infiltration in “oral malignant melanoma (OMM) in dogs,” a highly malignant and metastatic tumor with poor prognosis.
OMM can be resistant to existing immunotherapies, necessitating new treatment strategies. This study focused on “tumor-associated macrophages (TAMs),” which suppress antitumor immunity. Using canine OMM tumor tissues, comprehensive gene expression analysis (RNA-seq) and immunohistochemistry (IHC) revealed that TAMs infiltrate at a high frequency.
These findings are expected to lead to the development of novel OMM therapies targeting TAMs.
- Division of Translational Research for One Medicine
- Masaya Igase（Clinical Veterinary Science）
- Masashi Sakurai（Pathogenetic and Preventive Veterinary Science）
- Shusaku Shibutani（Pathogenetic and Preventive Veterinary Science）
- Takuya Mizuno （Clinical Veterinary Science）
- Paper Title: CXCL8 mediates macrophage migration in canine oral malignant melanoma
- Journal: Scientific Reports
- Publication Date: November 6, 2025 (online publication)
- Authors: Nao Okauchi, Shusaku Shibutani, Masashi Sakurai, Hiroka Yamamoto, Kazuhito Itamoto, Daiki Kato, Takayuki Nakagawa, Sadatoshi Maeda, Kenji Baba, Takuya Mizuno & Masaya Igase
- DOI: https://doi.org/10.1038/s41598-025-22749-x
- ＜Research-Related Inquiries＞
- Department of Veterinary Clinical Pathology
- Joint Faculty of Veterinary Medicine, Yamaguchi University
- Masaya Igase
- Email: m.igase@yamaguchi-u.ac.jp
- ＜Public Relations＞
- Yamaguchi University The Research Institute for Cell Design and Medical Science (Life Science Support Section, Academic Research Division)
- Tel: 0836-85-3065
- Email: sh088@yamaguchi-u.ac.jp