2026.01.23
Acute changes in indices of cardiac filling and function induced by high-dose intravenous methylprednisolone pulse therapy: a single-center prospective study
A research group led by Assistant Professor Takashi Nawata and Professor Motoaki Sano of the Division of Advanced Genome Editing Therapy has conducted a detailed evaluation of the effects of steroid pulse therapy—a common treatment for intractable diseases—on patient hemodynamics.
In a study of eight patients with autoimmune diseases, significantly elevated levels of cardiac stress markers (BNP and ANP) were observed in all cases following the therapy. Echocardiography also confirmed an increase in left atrial volume. These findings suggest that steroid pulse therapy may impose a significant burden on the heart, highlighting the need for careful management and preventive measures, such as the administration of diuretics, when treating patients with pre-existing cardiac conditions.
These results were published online in the international scientific journal Immunological Medicine on December 28, 2025.
- Division of Advanced Genome Editing Therapy
Takashi Nawata （Internal Medicine Ⅱ）
Motoaki Sano （Medicine and Clinical Science）
- Paper Title: Acute changes in indices of cardiac filling and function induced by high-dose intravenous methylprednisolone pulse therapy: a single-center prospective study
- Journal: Immunological Medicine
- Authors: Takashi Nawata, Kaori Murakawa, Kohei Goda, Chika Kayabe Kuroda, Junya Nawata, Hironori Ishiguchi, Ayumi Omuro, Takeshi Suetomi, Hitoshi Uchinoumi, Shinichi Okuda, Mototsugu Shimokawa, Hiroshi Nakamura, and Motoaki Sano
- Publication Date: December 28, 2025
- URL: https://doi.org/10.1080/25785826.2025.2608493
- ＜Regarding the content of the paper＞
University Hospital ,Internal Medicine Ⅱ
Assistant Professor Takashi Nawata
TEL: 0836-22-2248
E-mail: tnawata@ (followed by yamaguchi-u.ac.jp)
＜Regarding public relations＞ - Yamaguchi University Research Institute for Cell Design Medical Science
(Life Science Support Section, Academic Research Division) - Tel: 0836-85-3065
- Email: sh088@(followed by yamaguchi-u.ac.jp)