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2026.02.27

Frailty in COPD Patients Linked to 2.6-Fold Increase in Cardiovascular Risk: A 10-Year Long-Term Study

Overview


A research group at Yamaguchi University has demonstrated a strong correlation between the degree of “frailty” (a state of declined physical and cognitive function) and the incidence of major adverse cardiovascular events (MACE), such as myocardial infarction, heart failure, and stroke, in patients with chronic obstructive pulmonary disease (COPD).

Using a 10-year follow-up study based on a regional electronic health record network in Sado City, Niigata Prefecture, the study revealed that higher frailty severity significantly increases the risk of cardiovascular events. Notably, the risk in the “severe frailty” group was approximately 2.6 times higher than that in the “non-frailty” group. These findings indicate that frailty assessment, in addition to respiratory function, is a critical indicator for the prognostic management of COPD patients.

RICeD Member
  • Division of Advanced Genome Editing Therapy
  • 　　　Keiji Oishi (Respiratory Medicine)
  • 　　　Yoriyuki Murata (Respiratory Medicine)
  • Division of Systems Medicine and Informatics
  • 　　　Takeshi Abe (AISMEC)
  • 　　　Masahiko Nakatsui (AISMEC)
  • 　　　Yoshiyuki Asai (Systems Bioinformatics)
Paper Information
  • Article Title：Impact of Frailty on Major Adverse Cardiovascular Events in Chronic Obstructive Pulmonary Disease
  • Journal：International Journal of Chronic Obstructive Pulmonary Disease
  • Authors：Kazuki Hamada, Keiji Oishi, Tasuku Yamamoto, Yoriyuki Murata, Maki Asami-Noyama, Nobutaka Edakuni, Tsunahiko Hirano, Takeshi Abe, Masahiko Nakatsui, Yoshiyuki Asai, Kazuto Matsunaga
  • Publication Date：September 4, 2025
  • URL：https://doi.org/10.2147/COPD.S538054
Contact
  • ＜Research Inquiries＞
    Kazuto Matsunaga, M.D., Ph.D. Professor, Department of Respiratory Medicine and Infectious Diseases, Yamaguchi University Graduate School of Medicine
  • TEL: 0836-22-3123
  • E-mail: kazmatsu@ (followed by yamaguchi-u.ac. )
    ＜Public Relations＞
  • Media and Public Relations: Institute of Cell Design and Biomedical Sciences (ICDBS), Yamaguchi University (Research Institute Section, Life Science Support Division, Academic Research Department)
  • TEL: 0836-85-3065
  • E-mail: sh088 (followed by yamaguchi-u.ac. )

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