2026.03.18
Three-Year Follow-Up of the PACI Randomized Controlled Trial (PACI-ON): Effects of Early Intervention for Atopic Dermatitis on Atopic March
A collaborative research team has demonstrated for the first time in the world that early intensive treatment for atopic dermatitis in early infancy is associated with a lower prevalence of food allergies even at the age of three. This finding is based on a long-term follow-up study of a multicenter randomized controlled trial (RCT).
The team includes researchers from the National Center for Child Health and Development (NCCHD) Allergy Center, Nagoya City University, Osaka Habikino Medical Center, Kindai University Faculty of Medicine, Yamaguchi University, Mie National Hospital, Chiba University, Fujita Health University Bantane Hospital, Public Showa Hospital, Nagoya University, and Akita University.
The results of this study have been published in the international journal, “Allergy.“
- Division of Advanced Genome Editing Therapy
- Shunji Hasegawa（Pediatrics）
- Title：Three-year follow-up of the PACI randomized controlled trial (PACI-ON): effects of early intervention for atopic dermatitis on atopic march
- Authors：Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Miori Sato, Fumi Ishikawa, Kenji Toyokuni, Yusuke Inuzuka, Tomoki Yaguchi, Hisako Ogasawara, Mami Shimada, Shigenori Kabashima, Katsuhito Iikura, Kunihiko Tsuchiya, Mariko Morimoto, Risa Tamagawa-Mineoka, Koji Masuda, Hajime Hosoi, Norito Katoh, Makoto Kameda, Yuri Takaoka, Amane Shigekawa, Yutaka Takemura, Alexandre Xu, Sakura Sato, Motohiro Ebisawa, Takaaki Itonaga, Shunji Hasegawa, Hiroyuki Wakiguchi, Takao Fujisawa, Rei Kanai, Fumiya Yamaide, Taiji Nakano, Osamu Natsume, Ryuhei Yasuoka, Yasuto Kondo, Yuji Mori, Takahiro Kawaguchi, Masaki Futamura, Kazumitsu Sugiura, Hiroshi Kitazawa, Yuko Hamahata, Masashi Akiyama, Michihiro Kono, Kyongsun Pak, Tatsuki Fukuie, Tohru Kobayashi, Hirohisa Saito, Hywel C. Williams, Yukihiro Ohya
- Affiliations：National Center for Child Health and Development (Tokyo)
- Graduate School of Medical Science, Kyoto Prefectural University of Medicine (Kyoto)
- Osaka Habikino Medical Center (Osaka)
- Faculty of Medicine, Kindai University (Osaka)
- National Hospital Organization Sagamihara National Hospital (Kanagawa)
- Graduate School of Medicine, Yamaguchi University (Yamaguchi)
- Faculty of Medicine, Oita University (Oita)
- National Hospital Organization Mie National Hospital (Mie)
- Graduate School of Medicine, Chiba University (Chiba)
- Hamamatsu University School of Medicine (Shizuoka)
- Fujita Health University Bantane Hospital (Aichi)
- Public Showa Hospital (Tokyo)
- National Hospital Organization Nagoya Medical Center (Aichi)
- School of Medicine, Fujita Health University (Aichi)
- Tohoku Medical and Pharmaceutical University (Miyagi)
- Saitama City Hospital (Saitama)
- Graduate School of Medicine, Nagoya University (Aichi)
- Graduate School of Medicine, Akita University (Akita)
- Lifespan and Population Health, University of Nottingham (UK)
- Graduate School of Medical Sciences, Nagoya City University (Aichi)
- ＜Regarding public relations＞
- Yamaguchi University Research Institute for Cell Design Medical Science (Life Science Support Section, Academic Research Division)
- TEL: 0836-85-3065
- E-mail: sh088@ ( followed by yamaguchi-u.ac.jp)