2026.03.31
Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels
A research group led by Professor Takeshi Ohama (Joint Faculty of Veterinary Medicine, Yamaguchi University; Member of the Institute for Cell Design Medical Science) and Ph.D. student Sana Ando (Graduate School of Joint Veterinary Medicine, Yamaguchi University) has elucidated a novel mechanism for the degradation of “c-Myc,” a protein deeply involved in cancer progression. Their study revealed that the degradation pathway of c-Myc switches depending on the levels of the tumor suppressor “PP2A.” These findings were published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).
- Division of Translational Research for One Medicine
- Takeshi Ohama (Basic Veterinary Science)
- Shunya Tsuji (Basic Veterinary Science)
- Koichi Sato (Basic Veterinary Science)
- Division of Advanced Cell Therapy
- Hiroaki Nagano (Gastroenterological, Breast and Endocrine Surgery)
- Ryoichi Tsunetomi (Surgery Ⅱ)
- Title：Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels
- Journal：Proceedings of the National Academy of Sciences of the United States of America (PNAS)
- Authors：Ando S, Ikeda S, Tanaka K, Tomabechi Y, Yamagata A, Shirouzu M, Tsunedomi R, Nagano H, Tsuji S, Sato K, Ohama T
- Publication Date：March 17，2026
- DOI：10.1073/pnas.2509374123
- ＜Regarding the Research＞
- Professor Takeshi Ohama （Laboratory of Veterinary Physiology）
- Joint Faculty of Veterinary Medicine,
- Yamaguchi University
- Tel: 083-933-5906
- E-mail: t.ohama@ （followed by yamaguchi-u.ac.jp）
- ＜Regarding Public Relations＞
- Research Institute for Cell Design Medical Science (RICeD)
- (Research Support Division, Life Science Support Section, Yamaguchi University)
- Tel: 0836-85-3065
- E-mail: sh088@ (followed by yamaguchi-u.ac.jp)