研究業績

Kume K, Kurashige T, Muguruma K, Morino H, Tada Y, Kikumoto M, Miyamoto T, Akutsu SN, Matsuda Y, Matsuura S, Nakamori M, Nishiyama A, Izumi R, Niihori T, Ogasawara M, Eura N, Kato T, Yokomura M, Nakayama Y, Ito H, Nakamura M, Saito K, Riku Y, Iwasaki Y, Maruyama H, Aoki Y, Nishino I, Izumi Y, Aoki M, Kawakami H.CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis. Am J Hum Genet, 110(7):1086-1097, 2023
Kimura S, Morita T, Hosoba K, Itoh H, Yamamoto T, Miyamoto T. Cholesterol in the ciliary membrane as a therapeutic target against cancer. Front Mol Biosci, 10:1160415,2023
Hosoba K, Morita T, Zhang Y, Kishi H, Yamamoto T, Miyamoto T. High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies. Methods Cell Biol, 175:85-95 2023
Morita T, Hosoba K, Miyamoto T. Elucidation of the etiological mechanisms underlying rare hereditary cilia/centrosome disorders using genome editing technology. Gene and Genome editing, 3-4, 100016, 2022
Kitagawa T, Kobayashi D, Baron B, Okita H, Miyamoto T, Takai R, Paudel D, Ohta T, Asaoka Y, Tokunaga M, Nakagawa K, Furutani-Seiki M, Araki N, Kuramitsu Y, Kobayashi M. AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells. PLoS One,17(10), e0269077, 2022
Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J. Sulphoraphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ Breast Cancer, 8(1):40, 2022
Akutsu SN, Miyamoto T, Oba D, Tomioka K, Ochiai H, Ohashi H, Matsuura S. iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes. Plos One, 17(3):e0264965, 2022
Miyamoto T, Hosoba K, Akutsu SN, Matsuura S. Imaging of ciliary cholesterol underlying the sonic hedgehog signal transduction. Methods in Mol Biol, 2374:49-57, 2022.
Lu Q, Kishi H, Zhang Y, Morita T, Kobayashi S. Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway. J Cardiovasc Pharmacol,79(4):456-466, 2022
Zhang Y, Kishi H, Morita T, Kobayashi S. Paxillin controls actin stress fiber formation and migration of vascular smooth muscle cells by directly binding to the active Fyn. FASEB J,35(12): e22012, 2021
Tomioka K#, Miyamoto T#, Akutsu SN, Yanagihara H, Fujita K, Royba E, Tauchi H, Yamamoto T, Koh I, Hirata E, Kudo Y, Kobayashi M, Okada S, Matsuura S (# equal contribution). NBS1 I171V variant underlies individual differences in chromosomal radiaosensitivity within human populations. Scientific Rep, 11(1):19661, 2021
Kobayashi Y, Tomoshige S, Imakado K, Sekino Y, Koganezawa N, Shirao T, Diniz GB, Miyamoto T, Saito Y. Ciliary GPCR-based transcriptome as a key regulator as cilia length control. FASEB BioAdvances, 3(9):744-767, 2021
Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S. Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome. EMBO J, 19(12): e103499, 2020
Fujita H, Sasaki T, Miyamoto T, Akutsu SN, Sato S, Mori T, Nakabayashi K, Hata K, Suzuki H, Kosaki K, Matsuura S, Matsubara Y, Amagai M, Kubo A*. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. Aging Cell, 19(11):e13251, 2020
Lin Y, Nakatochi M, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H,Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Hosono Y, Ebi H, Kohmoto T, Imoto I, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Wakai K, Yamaji T, Iwasaki M, Sawada N, Tsugane S, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka A, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nature Commun, 11(1):3175, 2020
Furukawa S, Nagamatsu A, Neoi M, Fujimori A, Kakinuma S, Katsube T, Wang B, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, Takahashi A.: Space Radiation Biology for “Living in Space”. BioMed Res Int, 2020: Article ID 4703286, 2020
Akutsu SN, Fujita K, Tomioka K, Miyamoto T, Matsuura S: Applications of genome editing technology in research on chromosome aneuploidy disorders. Cells. 9(1):234, 2020
Yukimoto H, Miyamoto T, Kiyono T, Wang S, Matsuura S, Mizoguchi A, Katayama N, Inagaki M, Kasahara K: A novel CDK-independent function of p27Kip1 in preciliary vesicle trafficking during ciliogenesis. Biochem Biophys Res Commun,527(3):716-722, 2020
Miki D, Kobayashi Y, Okada T, Miyamoto T, Takei N, Sekino Y, Koganezawa N, Shirao T, Saito Y: Characterization of functional primary cilia in human induced pluripotent stem cell-derived neurons. Neurochem Res, 44(7):1736-1744, 2019
Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, Inagaki M, Hayashi Y: Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Genes Cells, 23 (12):1023-1042, 2018
Takebayashi-Suzuki K, Konishi H, Miyamoto T, Nagata T, Suzuki A: Coordinated regulation of the dorsal-ventral and anterior-posterior patterning of Xenopus embryos by the BTB/POZ zinc finger protein Zbtb14. Dev Growth Differ, 60(3):158-173, 2018
Miyamoto T, Akustsu SN, Tauchi H, Kudo Y, Tashiro S, Yamamoto T, Matsuura S: Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology. J Radiat Res, 59(suppl_2):ii75-ii82, 2018
Miyamoto T, Akutsu SN, Matsuura S: Updated summary of genome editing technology in human cultured 　cells linked to human genetics studies. J. Hum Genet, 63(2):133-143, 2017
Miyamoto T, Akutsu SN, Fukumitsu A, Morino H, Masatsuna Y, Hosoba K, Kawakami H, Yamamoto T, Shimizu K, Ohashi H, Matsuura S: PLK1-meditaed phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation. Hum Mol Genet, 26(22):4429-4440, 2017
Tomoshige S, Kobayashi Y, Hosoba K, Hamamoto A, Miyamoto T, Saito Y: Cytoskelton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1. Gen Comp Endocrinol, 253:44-52, 2017
Royba E, Miyamoto T, Akutsu SN, Hosoba K, Tauchi H, Kudo Y, Tashiro S, Yamamoto T, Matsuura S: Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells. Scientific Rep, 7(1):5996,2017
Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa. Matrix Biol, 56:132-149, 2016
Matsuura S, Royba E, Akutsu SN, Yanagihara H, Ochiai H, Kudo Y, Tashiro S, Miyamoto T: Analysis of individual differences in radiosensitivity using genome editing. Ann ICRP, 45(1Suppl):290-296, 2016
Takemoto A, Miyamoto T, Simono F, Kurogi N, Shirae-Kurabayashi M, Awazu A, Suzuki KT, Yamamoto T, Sakamoto N. Cilia play a role in breaking left-right symmetry of the sea urchin embryo. Genes Cells, 21(6):568-578, 2016
Miyamoto T, Matsuura S: Ciliopathy in PCS (MVA) syndrome. Oncotarget, 6(28):24582-3, 2015
Porazinski S#, Wang H#, Asaoka Y#, Behrndt M#, Miyamoto T#, Morita H, Hata S, Sasaki T, Krens SF, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Castillo-Morales A, Urrutia AO, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M (#Equal contribution): YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature, 521(7551):217-221, 2015
Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S: The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation. Cell Reports, 10:664-673, 2015
Ochiai H#, Miyamoto T#, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii K, Yamamoto T, Matsuura S. (#Equal contribution): TALEN-mediated single-base-pair editing identification of an intergenic mutation of upstream of BUB1B as causative of PCS (MVA) syndrome. Proc Natl Acad Sci USA, 111：1461-1466, 2014
Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Scientific Rep, 3: 3379, 2013
Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T: Efficient TALEN construction and evaluation methods for human cell and animal applications. Genes Cells, 18: 315-326, 2013
Ochiai H, Sakamoto N, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Shibata T, Yamamoto T: Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos. Proc Natl Acad Sci USA, 109：10915−10920, 2012
Miyamoto T, Porazinski S, Wang H, Borovina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S: Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum Mol Genet,20(10):2058-2070, 2011
Miyamoto T, Furuse M, Furutani-Seiki M: In Vivo Imaging of Tight Junctions Using Claudin-EGFP transgenic Medaka. Methods in Mol Biol, 10(3):314-321, 2011
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Matsuura S: Two unrelated patients with MRE11A mutations and Nijimegen breakage syndrome-like severe microcephaly. DNA Repair (Amst), 10(3):314-321, 2011
Fujita K, Takeuchi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T: HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development. Mech Dev, 127(3-4):235-245, 2010
Miyamoto T, Momoi A, Kato K, Kondoh K, Tsukita S, Furuse M, Furutani-Seiki M: Generation of transgenic medaka expressing Claudin7-EGFP for imaging of tight junctions in living medaka embryos. Cell Tissue Res, 335(2):465-471, 2009
Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T, Nakayama K, Okamura Y, Sasaki H, Miyachi Y, Furuse M, Tsukita S: Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol, 169(3):527-38, 2005
Kitajiri S#, Miyamoto T#, Mineharu A, Sonoda N, Furuse K, Hata M, Sasaki H, Mori Y, Kubota T, Ito J, Furuse M, Tsukita S. (#Equal contribution): Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J Cell Sci, 117(Pt 21):5087-96, 2004